polymyxin B sulfate and trimethoprim (Polytrim)

  • Pharmacy Author:
    Omudhome Ogbru, PharmD

    Dr. Ogbru received his Doctorate in Pharmacy from the University of the Pacific School of Pharmacy in 1995. He completed a Pharmacy Practice Residency at the University of Arizona/University Medical Center in 1996. He was a Professor of Pharmacy Practice and a Regional Clerkship Coordinator for the University of the Pacific School of Pharmacy from 1996-99.

  • Medical and Pharmacy Editor: Charles Patrick Davis, MD, PhD
    Charles Patrick Davis, MD, PhD

    Charles Patrick Davis, MD, PhD

    Dr. Charles "Pat" Davis, MD, PhD, is a board certified Emergency Medicine doctor who currently practices as a consultant and staff member for hospitals. He has a PhD in Microbiology (UT at Austin), and the MD (Univ. Texas Medical Branch, Galveston). He is a Clinical Professor (retired) in the Division of Emergency Medicine, UT Health Science Center at San Antonio, and has been the Chief of Emergency Medicine at UT Medical Branch and at UTHSCSA with over 250 publications.

GENERIC NAME: polymyxin B sulfate and trimethoprim

BRAND NAME: Polytrim



PRESCRIBED FOR: Polymyxin B sulfate/trimethoprim is used for treating bacterial conjunctivitis and blepharoconjunctivitis in the eyes.

SIDE EFFECTS: Side effects of polymyxin B sulfate/trimethoprim are

  • redness,
  • itching, and
  • irritation.
  • Hypersensitivity reactions like edema (swelling) and rash may occur.

PREPARATIONS: Polymyxin B sulfate/trimethoprim is a sterile eye drop, containing polymyxin B sulfate 10,000 units/ml and trimethoprim sulfate 1 mg/ml, available in 10 ml dispenser bottles.

DRUG INTERACTIONS: Drug interactions have not been established for polymyxin B sulfate/trimethoprim combination eye drops.

PREGNANCY AND BREASTFEEDING SAFETY: There are no adequate studies done on polymyxin B sulfate/trimethoprim to determine safe and effective use in pregnant women.

It is not known whether polymyxin B sulfate/trimethoprim enters breast milk. It is best use caution before using it in nursing mothers.

Medically Reviewed by a Doctor on 7/11/2016
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