polymyxin B sulfate and trimethoprim (Polytrim)

GENERIC NAME: polymyxin B sulfate and trimethoprim

BRAND NAME: Polytrim

DRUG CLASS AND MECHANISM: Polymyxin B sulfate/trimethoprim is an antibiotic eye drop composed of two drugs. Polymyxin B sulfate works by altering bacterial cell wall structure that causes the leaking out of cellular contents that can result in cell death. Trimethoprim is an antibiotic that interferes with the production of tetrahydrofolic acid, a chemical that is necessary for bacteria and human cells to produce proteins. Trimethoprim inhibits production of tetrahydrofolic acid by inhibiting the enzyme responsible for making tetrahydrofolic acid from dihydrofolic acid. This inhibition interferes with the ability of bacteria to survive. Polymyxin B sulfate/trimethoprim is effective against gram-positive and gram-negative bacteria such as Staphylococcus aureus and epidermis, Streptococcus pyogenes, Streptococcus faecalis, Streptococcus pneumonia, E. coli, Haemophilus influenzae, Klebsiella pneumoniae, and Pseudomonas aeruginosa. The FDA approved polymyxin B sulphate/trimethoprim in October 1988.

PRESCRIPTION: Yes

GENERIC AVAILABLE: Yes

PREPARATIONS: Polymyxin B sulfate/trimethoprim is a sterile eye drop, containing polymyxin B sulfate 10,000 units/ml and trimethoprim 1 mg/ml, available in 10 ml dispenser bottles.

Medically Reviewed by a Doctor on 10/24/2014



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