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Polyarteritis Nodosa (cont.)

How is polyarteritis treated?

Polyarteritis is a serious illness that can be fatal. Treatment is directed toward decreasing the inflammation of the arteries by suppressing the immune system. Medications used to treat polyarteritis nodosa include high-dose intravenous and oral cortisone medications such as prednisone, as well as immunosuppressive drugs such as cyclophosphamide (Cytoxan) or azathioprine (Imuran).

When hepatitis B is present in patients with polyarteritis, antiviral medications (such as vidarabine and interferon-alpha) are used as primary treatments. Some studies have used various combinations of antiviral medications, plasma exchange, and immunosuppressive drugs.

Polyarteritis Nodosa At A Glance
  • Polyarteritis nodosa is an autoimmune disease that affects arteries.
  • Common areas affected include the muscles, joints, intestines (bowels), nerves, kidneys, and skin.
  • Diagnosis of polyarteritis nodosa is confirmed by a biopsy of involved tissue or angiography.
  • Treatment is directed toward decreasing the inflammation of the arteries.

References:

Clinical Primer of Rheumatology, Lippincott Williams & Wilkens, edited by William Koopman, et al., 2003.

Kelley's Textbook of Rheumatology, W B Saunders Co, edited by Shaun Ruddy, et al., 2004.


Last Editorial Review: 9/11/2007




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