plicamycin-injection, Mithracin (cont.)

HOW TO USE: This is a potent medication. Take it exactly as prescribed. Do not stop taking this medication, even if you feel nauseated or experience vomiting. If you vomit shortly after a dose, or if you miss a dose, contact your doctor. Do not take any medicines for pain or inflammation, like aspirin or acetaminophen without first informing your doctor.

SIDE EFFECTS: Nausea, vomiting, loss of appetite, diarrhea, headache, irritated or sore mouth, tiredness, weakness, drowsiness or depression are common side effects. Taking the medication on an empty stomach may help relieve vomiting. Changes in diet such as eating several small meals or limiting activity may help lessen some of these effects. In some cases, drug therapy may be necessary to prevent or relieve nausea and vomiting. Temporary hair loss is another common side effect; normal hair growth should return after treatment has ended. Contact your doctor immediately if you experience any of the following symptoms: nosebleed, bloody or tarry stools, bloody vomit, sore throat, fever, unusual bleeding or bruising, small red spots on the skin, redness/flushing/swelling of the face, skin rash. If you notice other effects not listed above, contact your doctor or pharmacist.

PRECAUTIONS: Tell your doctor if you have: pre-existing kidney, liver disease, blood disorders. Plicamycin should not be used during pregnancy. If you become pregnant or think you may be pregnant, inform your doctor immediately. It is not known if plicamycin is excreted into breast milk. Consult your doctor before breast-feeding.

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You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.

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