Plague

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Plague facts

  • Plague is an infectious disease caused by the bacteria known as Yersinia pestis.
  • Plague has a high fatality rate and has been described for centuries.
  • In the Middle Ages, plague caused the death of 60% of the population of Europe.
  • Transmission occurs via fleas that feed on infected rodents.
  • There are three forms of plague in humans: bubonic plague, septicemic plague, and pneumonic plague.
  • Antibiotics are the treatment of choice for plague and are most effective when given early in the course of disease.
  • There is no commercially available vaccine against plague.
  • Plague may be found in low levels in animals in the southwestern U.S.
  • Diagnosis of plague depends upon identifying the causative bacteria in fluid or tissue samples.

What is plague? What is the history of plague?

Plague is a bacterial disease that is infamous for causing millions of deaths in the Middle Ages in Europe. Many historical references describe the illness, which has been referred to as the "Black Death." The first reported plague pandemic began in 541 A.D. and lasted for over 200 years, killing an estimated 100 million people or more throughout the Mediterranean basin. The so-called Black Death, or pandemic of the Middle Ages, began in China and made its way to Europe, causing the death of 60% of the entire population. The third, or modern, pandemic started in China in the 19th century and spread to port cities all over the world.

Rodents and many other kinds of animals can be infected with plague-causing bacteria. People contract the bacteria through bites of fleas that have fed on infected rodents. Humans can also develop the infection from handling fluids or tissues from infected animals. People with plague pneumonia can also transmit the infection to other humans via coughing infectious droplets into the air.

Medically Reviewed by a Doctor on 6/23/2014

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Plague & Bioterrorism

What are the biological agents that can be utilized for bioterrorism?

While any germ, bacteria, or virus could potentially be utilized by terrorist, there are a number of biological agents that have been recognized as being more likely to be utilized. The reason for these agents being of concern is based on their availability to terrorists and the ease by which these agents can be disseminated.


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