piperacillin and tazobactam (Zosyn) (cont.)

Pharmacy Author:
Medical and Pharmacy Editor:

Rare side effects occurring with a frequency of less than 1% are:

PRESCRIPTION: Yes

GENERIC AVAILABLE: Yes

PREPARATIONS:

  • Piperacillin and tazobactam for injection is supplied as a powder for reconstitution (mixing).
  • Powder for solution for injection: 2.25, 3.375, 4.5, 40.5 g

STORAGE: Piperacillin and tazobactam vials should be stored at controlled room temperature, between 20 C to 25 C (68 F to 77 F), before reconstitution.

ADULT DOSING: Piperacillin and tazobactam should be administered by intravenous infusion (IV) over 30 minutes. The usual daily dose for adults is 3.375 g every six hours (total daily dose 13.5 g).

  • Nosocomial pneumonia: The usual starting dose is 4.5 g intravenously every 6 hours plus an aminoglycoside for 7-14 days.
  • Community-acquired pneumonia: The usual recommended dose is 3.375 g intravenously every 6 hours for 7-10 days.
  • Skin and soft tissue infection: The usual recommended dose is 3.375 mg intravenously every 6-8 hours for 7-14 days.
  • Diverticulitis, intra-abdominal abscess, peritonitis: The usual recommended dose is 3.375 g intravenously every 6 hours for 7-10 days.

Piperacillin and tazobactam requires dose adjustment in patients with reduced kidney function.

PEDIATRIC DOSING: Manufacturer's recommendation for the treatment of appendicitis and/or peritonitis includes:

  • < 2 months: safety and efficacy is not established
  • Infants 2-9 months: 80 mg/kg IV every 8 hours
  • Infants and children =9 months, weighing =40 kg with normal renal function: 100 mg/kg IV every 8 hours
  • Pediatric patients > 40 kg with normal renal function: same as adult dose
Medically Reviewed by a Doctor on 12/12/2014


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