piperacillin and tazobactam (Zosyn)

  • Pharmacy Author:
    Omudhome Ogbru, PharmD

    Dr. Ogbru received his Doctorate in Pharmacy from the University of the Pacific School of Pharmacy in 1995. He completed a Pharmacy Practice Residency at the University of Arizona/University Medical Center in 1996. He was a Professor of Pharmacy Practice and a Regional Clerkship Coordinator for the University of the Pacific School of Pharmacy from 1996-99.

  • Medical and Pharmacy Editor: Jay W. Marks, MD
    Jay W. Marks, MD

    Jay W. Marks, MD

    Jay W. Marks, MD, is a board-certified internist and gastroenterologist. He graduated from Yale University School of Medicine and trained in internal medicine and gastroenterology at UCLA/Cedars-Sinai Medical Center in Los Angeles.

Bacterial Infections 101 Pictures Slideshow

PRESCRIPTION: Yes

GENERIC AVAILABLE: Yes

PREPARATIONS:

  • Piperacillin and tazobactam for injection is supplied as a powder for reconstitution (mixing).
  • Powder for solution for injection: 2.25, 3.375, 4.5, 40.5 g

STORAGE: Piperacillin and tazobactam vials should be stored at controlled room temperature, between 20 C to 25 C (68 F to 77 F), before reconstitution.

ADULT DOSING: Piperacillin and tazobactam should be administered by intravenous infusion (IV) over 30 minutes. The usual daily dose for adults is 3.375 g every six hours (total daily dose 13.5 g).

  • Nosocomial pneumonia: The usual starting dose is 4.5 g intravenously every 6 hours plus an aminoglycoside for 7-14 days.
  • Community-acquired pneumonia: The usual recommended dose is 3.375 g intravenously every 6 hours for 7-10 days.
  • Skin and soft tissue infection: The usual recommended dose is 3.375 mg intravenously every 6-8 hours for 7-14 days.
  • Diverticulitis, intra-abdominal abscess, peritonitis: The usual recommended dose is 3.375 g intravenously every 6 hours for 7-10 days.

Piperacillin and tazobactam requires dose adjustment in patients with reduced kidney function.

PEDIATRIC DOSING: Manufacturer's recommendation for the treatment of appendicitis and/or peritonitis includes:

  • < 2 months: safety and efficacy is not established
  • Infants 2-9 months: 80 mg/kg IV every 8 hours
  • Infants and children =9 months, weighing =40 kg with normal renal function: 100 mg/kg IV every 8 hours
  • Pediatric patients > 40 kg with normal renal function: same as adult dose

DRUG INTERACTIONS:

  • Probenecid may inhibit the renal tubular secretion (elimination via the kidneys) of piperacillin/tazobactam. This may cause higher, prolonged blood levels of piperacillin/tazobactam. The half-life of piperacillin is prolonged by 21% and the half-life of tazobactam by 71%.
  • Piperacillin/tazobactam may inhibit platelet aggregation (formation of a blood clot) which may increase the risk for bleeding. Co-administration with blood thinning agents such as warfarin (Coumadin) requires close monitoring for signs or symptoms of bleeding.
  • Piperacillin/tazobactam may prolong the neuromuscular blockade of vecuronium (Norcuron).
  • Piperacillin/tazobactam may decrease the renal (kidney) elimination of methotrexate (Trexall). Patients on concurrent therapy with methotrexate should be monitored frequently for signs or symptoms of methotrexate toxicity.
Medically Reviewed by a Doctor on 12/12/2014

Quick GuideInfectious Mononucleosis (Mono): Symptoms and Treatment

Infectious Mononucleosis (Mono): Symptoms and Treatment
FDA Logo

Report Problems to the Food and Drug Administration

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.

RxList Logo

Need help identifying pills and medications?

Use the pill identifier tool on RxList.

Subscribe to MedicineNet's Newsletters

Get the latest health and medical information delivered direct to your inbox!

By clicking Submit, I agree to the MedicineNet's Terms & Conditions & Privacy Policy and understand that I may opt out of MedicineNet's subscriptions at any time.

Health Solutions From Our Sponsors