piperacillin and tazobactam (Zosyn) (cont.)

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Medical and Pharmacy Editor:

PRESCRIBED FOR: Piperacillin and tazobactam is used for the treatment of moderate to severe infections caused by piperacillin-resistant, piperacillin/tazobactam susceptible, β-lactamase producing strains of bacteria implicated in the following specified conditions:

  • Community-acquired pneumonia (moderate severity only): caused by piperacillin-resistant, β-lactamase producing strains of Haemophilus influenzae.
  • Intra-abdominal infections: For the treatment of appendicitis complicated by rupture or abscess and peritonitis caused by piperacillin-resistant, β-lactamase producing strains of Staphylococcus aureus.
  • Pelvic infection: For the treatment of postpartum endometriosis or pelvic inflammatory disease caused by piperacillin-resistant, β-lactamase producing strains of Escherichia coli.
  • Nosocomial (hospital acquired) pneumonia: For the treatment of moderate to severe hospital acquired pneumonia caused by piperacillin-resistant, β-lactamase producing strains of Staphylococcus aureus and by piperacillin/tazobactam-susceptible Acinetobacter baumannii, Haemophilus influenzae, Klebsiella pneumonia, and Pseudomonas aeruginosa (nosocomial pneumonia caused by P. aeruginosa should be treated in combination with an aminoglycoside).
  • Skin and skin structure infections: For the treatment of skin and skin structure infections including cellulitis, cutaneous abscesses, and ischemic/diabetic foot infections caused by piperacillin-resistant, β-lactamase producing strains of Staphylococcus aureus.

SIDE EFFECTS: Common side effects associated with piperacillin/tazobactam include:

Medically Reviewed by a Doctor on 12/12/2014


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