pioglitazone, Actos

  • Pharmacy Author:
    Omudhome Ogbru, PharmD

    Dr. Ogbru received his Doctorate in Pharmacy from the University of the Pacific School of Pharmacy in 1995. He completed a Pharmacy Practice Residency at the University of Arizona/University Medical Center in 1996. He was a Professor of Pharmacy Practice and a Regional Clerkship Coordinator for the University of the Pacific School of Pharmacy from 1996-99.

  • Medical and Pharmacy Editor: Jay W. Marks, MD
    Jay W. Marks, MD

    Jay W. Marks, MD

    Jay W. Marks, MD, is a board-certified internist and gastroenterologist. He graduated from Yale University School of Medicine and trained in internal medicine and gastroenterology at UCLA/Cedars-Sinai Medical Center in Los Angeles.

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PREPARATIONS: Tablets: 15, 30 and 45 mg.

STORAGE: Tablets should be kept at room temperature, 15 C -30 C (59 F -86 F).

DOSING: Pioglitazone is prescribed once daily in doses ranging from 15 to 45 mg. The recommended starting dose for patients without heart failure is 15 or 30 mg and for those with heart failure it is 15 mg daily. The dose may be increased in 15 mg intervals to a maxiumu dose of 45 mg daily if needed. Pioglitazone may be taken any time of the day, with or without meals. If a dose is missed on one day, two doses should not be taken the next day to make up for the missed dose.

DRUG INTERACTIONS: Gemfibrozil reduces the break down of pioglitazone by certain liver enzymes, increasing blood levels and possibly side effects of pioglitazone. The maximum dose of pioglitazone should not exceed 15 mg daily when combined with gemfibrozil or other drugs that reduce the activity of liver enzymes that break down pioglitazone. Conversely, rifampin increases the breakdown of pioglitazone by the liver, reducing blood levels and possibly the effects of pioglitazone.

PREGNANCY: There are no adequate studies of pioglitazone in pregnant women. Pioglitazone may be used in pregnancy if the physician feels the potential risks are justified.

NURSING MOTHERS: It is unknown if pioglitazone is secreted in breast milk. Therefore, the effect of pioglitazone on the nursing infant whose mother is taking pioglitazone is unknown.

REFERENCE: FDA Prescribing Information

Medically Reviewed by a Doctor on 8/4/2015

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