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GENERIC NAME: PIMOZIDE - ORAL (PIM-oh-zide)

BRAND NAME(S): Orap

Medication Uses | How To Use | Side Effects | Precautions | Drug Interactions | Overdose | Notes | Missed Dose | Storage

USES: This medication works in the nervous system to help control involuntary or unconscious movements (tics) both physical and verbal. It is used to reduce tics in persons with Tourette's Disorder.

HOW TO USE: Take this medication exactly as prescribed. Do not take this more often or increase your dose without consulting your doctor. Your condition will not improve any faster and the risk of serious side effects will be increased. Your dose may be slowly and gradually increased or decreased at times to see if the tics continue. Follow any changes in dosing carefully. Do not stop taking this drug suddenly if you have been taking this for some time. Your dose should be gradually reduced over time. Do not eat grapefruit or drink grapefruit juice at any time while using this medication unless your doctor instructs you otherwise.

SIDE EFFECTS: Dry mouth, drowsiness, headache, stomach upset, change in appetite, or sleeplessness may occur the first several days as your body adjusts to the medication. Blurred vision, change in sex drive, nervousness, muscle cramps, behavior changes, or menstrual changes may also occur. If any of these effects persist or worsen, notify your doctor promptly. Notify your doctor immediately of: mental confusion, difficulty speaking, sweating, tremors, drooling, stiff muscles, difficulty walking, unusual eye movements, chest pain, increased body heat, abnormal tongue/face/jaw movements (puffing cheeks, chewing, puckering mouth), seizures. Tell your doctor immediately if any of these highly unlikely but very serious side effects occur: dizziness, fainting, irregular heartbeat. If you notice other effects not listed above, contact your doctor or pharmacist.

PRECAUTIONS: This medication should not be used if you have certain medical conditions. Before using this medicine, consult your doctor or pharmacist if you have: low blood potassium or magnesium levels, history of irregular heartbeat. Before using this medication, tell your doctor or pharmacist your medical history, especially of: pre-existing liver disease, kidney disease, heart disease, glaucoma, prostate problems, any allergies. This medication may cause blurred vision. Use caution operating machinery or engaging in activities requiring alertness. Avoid alcohol intake while taking this medication. This medication should be used only if clearly needed during pregnancy. Discuss the risks and benefits with your doctor. It is not known if this medication appears in breast milk. Consult your doctor before breast-feeding.




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You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.


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  • Tourette Syndrome - Read about Tourette syndrome, a neurological disorder that includes involuntary facial, motor, and vocal tics. Causes, diagnosis, and treatment information is included in the article.

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pimozide-oral, Orap

What is Tourette syndrome?

Tourette syndrome (TS) is a neurological disorder characterized by repetitive, stereotyped, involuntary movements and vocalizations called tics. The disorder is named for Dr. Georges Gilles de la Tourette, the pioneering French neurologist who in 1885 first described the condition in an 86-year-old French noblewoman.

The early symptoms of Tourette syndrome are almost always noticed first in childhood, with the average onset between the ages of 7 and 10 years. Tourette syndrome occurs in people from all ethnic groups; males are affected about three to four times more often than females. It is estimated that 200,000 Americans have the most severe form of Tourette syndrome, and as many as one in 100 exhibit milder and less complex symptoms such as chronic motor or vocal tics or transient tics of childhood. Although Tourette syndrome can be a chronic condition with symptoms lasting a lifetime, most people with the condit...

Read the Tourette Syndrome article »




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