- What is pilocarpine, and how does it work (mechanism of action)?
- What brand names are available for pilocarpine?
- Is pilocarpine available as a generic drug?
- Do I need a prescription for pilocarpine?
- What are the side effects of pilocarpine?
- What is the dosage for pilocarpine?
- Which drugs or supplements interact with pilocarpine?
- Is pilocarpine safe to take if I'm pregnant or breastfeeding?
- What else should I know about pilocarpine?
What is the dosage for pilocarpine?
Oral pilocarpine usually is taken three or four times daily. The recommended dose for radiation induced xerostomia is 5 to 10 mg three times daily.
The dose for xerostomia associated with Sjögren's syndrome is 5 mg four times daily. The maximum effect occurs in approximately one hour but may occur later if it is taken with food. The effects last three to five hours.
Which drugs or supplements interact with pilocarpine?
Medications that have anticholinergic effects should not be used with pilocarpine since they will counter pilocarpine's cholinergic effects. Such medications include atropine, for example, Lomotil; some antihistamines,for example, diphenhydramine (Benadryl), promethazine (Phenergan)], and trimeprazine (Temaril); some phenothiazines, for example, mesoridazine (Serentil), promazine (Sparine), thioridazine (Mellaril), and triflupromazine (Vesprin); some antidepressants, for example, amitriptyline (Elavil, Endep), amoxapine (Asendin), bupropion (Wellbutrin; Zyban), clomipramine (Anafranil), doxepin (Sinequan), maprotiline (Ludiomil), and protriptyline (Vivactil) as well as clozapine (Clozaril), cyclobenzaprine (Flexeril), and disopyramide (Norpace).
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