Photodynamic Therapy & Actinic Keratoses
What is the best way to treat actinic keratoses?
Overall, combination treatments using one or two types of therapies are best. For example, a good program may be to freeze the individual thick AKs with liquid nitrogen, allow them to heal for two to three weeks, and then treat the entire area with a field treatment like fluorouracil (Efudex) or photodynamic therapy.
Quick GuideUnderstanding Cancer: Metastasis, Stages of Cancer, and More
What is photodynamic therapy (PDT)?
Photodynamic therapy (PDT) is a medical treatment that utilizes a photosensitizing molecule (frequently a drug that becomes activated by light exposure) and a light source to activate the administered drug. Very thin superficial skin cancers called actinic keratoses and certain other types of cancer cells can be eliminated this way. Acne can also be treated as well. The procedure is easily performed in a physician's office or outpatient setting. PDT is also referred to as blue light therapy.
PDT essentially has three steps. First, a light-sensitizing liquid, cream, or intravenous drug (photosensitizer) is applied or administered. Occasionally, a photosensitizing molecule that is already part of the body can be activated. Second, there is an incubation period of minutes to days. Finally, the target tissue is then exposed to a specific wavelength of light that then activates the photosensitizing medication. The mechanism by which tissue is destroyed seems to depend on the presence of activated oxygen molecules.
- application of photosensitizer drug
- incubation period
- light activation
Although first used in the early 1900s, PDT in the modern sense is a new, evolving science. Current PDT involves a variety of incubation times for different the light-sensitizing drugs and a variety of light sources depending on the target tissue. The basic premise of PDT is selective tissue destruction.
At present, the primary limitation of available PDT technology for skin is the depth of penetration of the light and ability to target cells within 1/3 of an inch (approximately 1 cm) of the light source. Therefore, tumors or atypical growths must be close to the surface of the skin for PDT to work.
PDT is currently used in a number of medical fields, including oncology (cancer), dermatology (skin), cosmetic surgery, ophthalmology, and oral medicine.
In oncology, PDT is FDA approved for non-small cell lung cancer, esophageal cancer, and precancerous changes of Barrett's esophagus. Its use is also being further investigated through clinical trials in general oncology for conditions including cancers of the cervix (mouth of uterus), prostate gland, brain, and peritoneal cavity (the abdominal space that contains the stomach, liver, and internal organs).
Levulan stick (photosensitizer medication)
In dermatology, PDT with the photosensitizer Levulan Kerastick (20% delta-aminolevulinic acid HCl) is used for the treatment of very early, thin skin cancers called actinic keratoses (AK). The initial approval was specifically for the treatment of actinic keratosis of the face and scalp with application of the photosensitizer followed by a timed exposure to a special blue light source. PDT has also used for acne, rosacea, thin nonmelanoma skin cancers, sun damage, enlarged sebaceous glands, wrinkles, warts, hidradenitis suppurativa, psoriasis, and many other skin conditions. It is not used to remove moles or birthmarks.
Application of Levulan to the face
Medically Reviewed by a Doctor on 2/14/2017