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phenytoin extended capsule - oral, Dilantin (cont.)

PRECAUTIONS: Before taking phenytoin, tell your doctor or pharmacist if you are allergic to it; or to other anti-seizure medications (e.g., ethotoin, phenobarbital, ethosuximide, trimethadione); or if you have any other allergies.Before using this medication, tell your doctor or pharmacist your medical history, especially of: alcohol use, certain blood conditions (porphyria), diabetes, liver disease, lupus, folate or vitamin B-12 deficiency (megaloblastic anemia).This drug may make you dizzy or drowsy. Do not drive, use machinery, or do any activity that requires alertness until you are sure you can perform such activities safely. Limit alcoholic beverages. Alcohol may also affect your blood levels of this drug.Tell your doctor you are using phenytoin prior to surgery or any procedure that makes you unable to take it by mouth.If you have diabetes, this drug may increase your blood sugar levels. Check your blood (or urine) glucose level frequently, as directed by your doctor. Promptly report any abnormal results as directed. Your medicine, exercise plan, or diet may need to be adjusted.Vitamin D supplements may be necessary to prevent weakening of the bones (osteomalacia). Discuss this with your doctor.This medication is not recommended for use during pregnancy due to the possible risk of birth defects and harm to an unborn baby. Consult your doctor for more details.Phenytoin passes into breast milk. Consult your doctor before breast-feeding.

DRUG INTERACTIONS: Your doctor or pharmacist may already be aware of any possible drug interactions and may be monitoring you for them. Do not start, stop, or change the dosage of any medicine before checking with your doctor or pharmacist first.See also How to Use section.This drug should not be used with the following medications because very serious interactions may occur: azapropazone, darunavir, delavirdine, dofetilide, etravirine, nisoldipine, telithromycin.If you are currently using any of these medications, tell your doctor or pharmacist before starting phenytoin.Before using this medication, tell your doctor or pharmacist of all prescription and nonprescription/herbal products you may use, especially of: colesevelam, molindone, pyridoxine (vitamin B6), sucralfate, sulfa drugs, drugs affecting liver enzymes that remove phenytoin from your body (such as amiodarone, azole antifungals including itraconazole, cimetidine, ciprofloxacin, macrolide antibiotics including erythromycin, estrogens, isoniazid, rifamycins including rifabutin, St. John's wort, other anti-seizure medicines including carbamazepine/phenobarbital/valproic acid).Phenytoin can speed up the removal of many other drugs from your body by affecting certain liver enzymes. This can affect how well these other drugs work. These other drugs include: some drugs to treat cancer (e.g., imatinib, irinotecan), corticosteroids (e.g., prednisone), cyclosporine, felodipine, quetiapine, quinidine, theophylline, vitamin D, warfarin. This is not a complete list. Tell your doctor or pharmacist of all other drugs you take.Also report the use of drugs which might increase seizure risk (decrease seizure threshold) such as: phenothiazines (e.g., thioridazine) or tricyclic antidepressants (e.g., amitriptyline), among others. Consult your doctor or pharmacist for details.Phenytoin may decrease the effectiveness of birth control pills, patches, implants or injections. This can result in pregnancy. You may need to use an additional form of reliable birth control while using this medication. Consult your doctor or pharmacist for details.This product can affect the results of certain lab tests. Make sure laboratory personnel and your doctors know you use this drug.This document does not contain all possible interactions. Therefore, before using this product, tell your doctor or pharmacist of all the products you use. Keep a list of all your medications with you, and share the list with your doctor and pharmacist.



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