phenytoin, Dilantin, Dilantin-125 (cont.)

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DRUG INTERACTIONS: There are many potential drug interactions with phenytoin. Phenytoin can increase the metabolism (elimination) of many drugs, reducing their concentrations in the body. Drugs that may be affected include:

Phenytoin can interact with these drugs not only when it is added to therapy but also when it is discontinued. In the latter case, the concentration of the other drugs may increase. Sometimes the effect may be unpredictable. Phenytoin's metabolism may be affected by other drugs. Drugs that increase phenytoin blood levels and toxicity include:



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