Phenylephrine should be used with caution with antidepressants like amitriptyline (Elavil, Endep), nortriptyline (Pamelor, Aventyl), doxepin (Sinequan, Adapin), and trazodone (Deyrel). Such anti-depressants may increase blood pressure if used together with phenylephrine.
PREGNANCY: There are no adequate studies done on phenylephrine to determine safe and effective use in pregnant women.
NURSING MOTHERS: It is not known whether phenylephrine enters breast milk; therefore, it is best to be cautious before using it in nursing mothers.
FDA Prescribing Information.
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