phenylephrine hydrochloride (NeoSynephrine, Neofrin) (cont.)

DRUG INTERACTIONS: Phenylephrine should be used cautiously with MAO inhibitors like selegiline (Eldepryl, Zelapar), phenelzine (Nardil), isocarboxazid (Marplan), because they can also increase blood pressure and can cause a serious hypertensive episode. A similar reaction occurs when phenylephrine is combined with amphetamine and related drugs.

Phenylephrine should be used with caution with antidepressants like amitriptyline (Elavil, Endep), nortriptyline (Pamelor, Aventyl), doxepin (Sinequan, Adapin), and trazodone (Deyrel). Such anti-depressants may increase blood pressure if used together with phenylephrine.

PREGNANCY: There are no adequate studies done on phenylephrine to determine safe and effective use in pregnant women.

NURSING MOTHERS: It is not known whether phenylephrine enters breast milk; therefore, it is best to be cautious before using it in nursing mothers.

SIDE EFFECTS: Side effects of phenylephrine are headache, reflex bradycardia (slow heart beat), excitability, anxiety, restlessness, high blood pressure, and rarely abnormal heart beats.

REFERENCES:

FDA Prescribing Information.

Medscape. phenylephrine.


Medically Reviewed by a Doctor on 7/30/2014


Report Problems to the Food and Drug Administration

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.

Pill Finder Tool

Need help identifying pills and medications?
Use the pill identifier tool on RxList.


Back to Medications Index