phenylephrine hydrochloride (NeoSynephrine, Neofrin) (cont.)
DRUG INTERACTIONS: Phenylephrine should be used cautiously with MAO inhibitors like selegiline (Eldepryl, Zelapar), phenelzine (Nardil), isocarboxazid (Marplan), because they can also increase blood pressure and can cause a serious hypertensive episode. A similar reaction occurs when phenylephrine is combined with amphetamine and related drugs.
Phenylephrine should be used with caution with antidepressants like amitriptyline (Elavil, Endep), nortriptyline (Pamelor, Aventyl), doxepin (Sinequan, Adapin), and trazodone (Deyrel). Such anti-depressants may increase blood pressure if used together with phenylephrine.
PREGNANCY: There are no adequate studies done on phenylephrine to determine safe and effective use in pregnant women.
NURSING MOTHERS: It is not known whether phenylephrine enters breast milk; therefore, it is best to be cautious before using it in nursing mothers.
Medically Reviewed by a Doctor on 7/30/2014
Report Problems to the Food and Drug Administration
You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.
Need help identifying pills and medications?
Back to Medications Index