phenylbutazone, Butazolidine (cont.)

Pharmacy Author:
Medical and Pharmacy Editor:

PRESCRIBED FOR: Phenylbutazone is used for the treatment of inflammation and pain that results from rheumatoid arthritis, ankylosing spondylitis, gouty arthritis, and osteoarthritis.

SIDE EFFECTS: Most patients benefit from NSAIDs with little side effects. However, serious side effects can occur, and generally tend to be dose related. Phenylbutazone is not a commonly used NSAID because of a unique potential for severe bone marrow toxicity, which results in dangerously low white blood cell counts. Therefore, it is often desirable to use the lowest effective dose to minimize side effects. The most common side effects of phenylbutazone involve the gastrointestinal system.

Other important side effects include:

  • ulcerations,
  • abdominal burning,
  • pain,
  • cramping,
  • nausea,
  • gastritis,
  • serious gastrointestinal bleeding, and
  • liver toxicity.

Sometimes, stomach ulceration and bleeding can occur without any abdominal pain. Black tarry stools, weakness, and dizziness upon standing may be the only signs of internal bleeding. Rash, kidney impairment, ringing in the ears, and lightheadedness are also seen (all more frequently in seniors).


Medically Reviewed by a Doctor on 5/28/2015

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