Other important side effects include:
- abdominal burning,
- serious gastrointestinal bleeding, and
- liver toxicity.
Sometimes, stomach ulceration and bleeding can occur without any abdominal pain. Black tarry stools, weakness, and dizziness upon standing may be the only signs of internal bleeding. Rash, kidney impairment, ringing in the ears, and lightheadedness are also seen (all more frequently in seniors).
GENERIC AVAILABLE: yes
PREPARATIONS: Capsules and tablets: 100mg.
STORAGE: Store at room temperature, sealed container, avoid moisture.
DOSING: Should be taken with food.
DRUG INTERACTIONS: Phenylbutazone should be avoided by patients with a history of asthma attacks, hives, or other allergic reactions to aspirin or other NSAIDs. Rare but severe allergic reactions have been reported in such individuals. It also should be avoided by patients with peptic ulcer disease or poor kidney function, since this medication can aggravate both conditions. Phenylbutazone is generally used with caution in patients taking blood thinning medications (anticoagulants), such as warfarin (Coumadin), because of an increased risk of bleeding. Patients taking lithium (Eskalith, Lithobid) can develop toxic blood lithium levels. Additionally, patients taking cyclosporine (Sandimmune) can develop kidney toxicity. Use in children has not been adequately studied. Phenylbutazone is not habit forming. NSAIDs should be discontinued prior to elective surgery because of a mild interference with clotting that is characteristic of this group of medicines. Phenylbutazone is best discontinued at least three days in advance of the procedure.
PREGNANCY: Phenylbutazone is generally avoided during pregnancy.
NURSING MOTHERS: Phenylbutazone is generally avoided in nursing mothers.
Reference: FDA Prescribing Information
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