Qsymia (phentermine and topiramate extended-release )

  • Pharmacy Author:
    Omudhome Ogbru, PharmD

    Dr. Ogbru received his Doctorate in Pharmacy from the University of the Pacific School of Pharmacy in 1995. He completed a Pharmacy Practice Residency at the University of Arizona/University Medical Center in 1996. He was a Professor of Pharmacy Practice and a Regional Clerkship Coordinator for the University of the Pacific School of Pharmacy from 1996-99.

  • Medical and Pharmacy Editor: Charles Patrick Davis, MD, PhD
    Charles Patrick Davis, MD, PhD

    Charles Patrick Davis, MD, PhD

    Dr. Charles "Pat" Davis, MD, PhD, is a board certified Emergency Medicine doctor who currently practices as a consultant and staff member for hospitals. He has a PhD in Microbiology (UT at Austin), and the MD (Univ. Texas Medical Branch, Galveston). He is a Clinical Professor (retired) in the Division of Emergency Medicine, UT Health Science Center at San Antonio, and has been the Chief of Emergency Medicine at UT Medical Branch and at UTHSCSA with over 250 publications.

GENERIC NAME: phentermine and topiramate extended-release





  • Qsymia is an oral weight loss medicine that may help some obese adults (body mass index [BMI] = 30 km/m2) or some overweight adults (BMI = 27 km/m2) with weight-related medical problems such as high blood pressure, type 2 diabetes, or dyslipidemia lose weight and keep the weight off. To achieve maximum weight loss, Qsymia should be used with a reduced calorie diet and increased physical activity.
  • The safety and effectiveness of Qsymia with other prescription, over-the-counter (OTC), or herbal weight loss medications has not been established. Therefore, use of Qsymia with such agents is not recommended.
  • The safety and effectiveness of Qsymia has not been established in pediatric patients. Therefore, use of Qsymia in pediatrics is not recommended.

SIDE EFFECTS: The most common side effects of Qsymia are:

Rare, but serious side effects associated with Qsymia therapy include mood changes, trouble sleeping, problems with concentration or memory, speech difficulties, an increase in acid levels in the blood, low blood sugar especially in patients with type 2 diabetes mellitus who are also taking medicines to treat their blood sugar, seizures, kidney stones, decreased sweating, and fever.

Medically Reviewed by a Doctor on 6/24/2016
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