phentermine, Adipex-P, Fastin, Obenix, Oby-Trim
Omudhome Ogbru, PharmD
Omudhome Ogbru, PharmD
Dr. Ogbru received his Doctorate in Pharmacy from the University of the Pacific School of Pharmacy in 1995. He completed a Pharmacy Practice Residency at the University of Arizona/University Medical Center in 1996. He was a Professor of Pharmacy Practice and a Regional Clerkship Coordinator for the University of the Pacific School of Pharmacy from 1996-99.
Medical and Pharmacy Editor:
GENERIC NAME: phentermine
BRAND NAMES: Adipex-P, Obenix, Oby-Trim
DRUG CLASS AND MECHANISM: Phentermine is a drug that suppresses appetite. Its exact mechanism of action is unknown. It probably decreases appetite by acting on centers in the brain that control appetite. Phentermine is similar to amphetamine. It stimulates the nervous system, elevates blood pressure, and increases heart rate.
GENERIC AVAILABLE: Yes
PREPARATIONS: Tablets: 30 and 37.5mg.
STORAGE: Phentermine should be stored in a tight container at room temperature.
PRESCRIBED FOR: Phentermine is combined with diet and exercise for the short-term treatment of obesity in individuals with a body mass index greater than or equal to 30 kg/m2 or greater than or equal to 27 kg/m2 with risk factors for heart disease. Phentermine should not be combined with other weight loss agents. The combination of phentermine and fenfluramine (FEN-PHEN) is associated with serious heart problems. Fenfluramine is no longer available in the United States.
DOSING: The recommended dose is 30 mg once daily about 2 hours after breakfast. Evening doses should be avoided because phentermine causes insomnia.
DRUG INTERACTIONS: Phentermine is similar to amphetamine and may share some of the interactions associated with amphetamines. Combining phentermine with tricyclic antidepressants [for example, amitriptyline (Elavil, Endep)] or monoamine oxidase inhibitors (for example, tranylcypromine) may result in high blood pressure and other serious reactions because of elevated serotonin levels in the blood.
PREGNANCY: Use of phentermine during pregnancy has not been adequately evaluated.
NURSING MOTHERS: It is not known whether phentermine is excreted in human breast milk.
SIDE EFFECTS: Side effects of phentermine include nausea, vomiting, diarrhea, dry mouth, constipation, an unpleasant taste, hives, impotence, palpitations, high blood pressure, and fast heart rates (palpitations). Central nervous system side effects include hyperactivity, insomnia, restlessness, tremor, and dizziness. Phentermine, especially when combined with fenfluramine, has been associated with high pressures in the pulmonary arteries (pulmonary hypertension) and defects in heart valves, both serious complications. Physical and psychological dependence may occur with the long-term use of phentermine. A withdrawal reaction, which includes excessive drowsiness, fatigue, tremors and depression may occur after prolonged use.
Reference: FDA Prescribing Information
Last Editorial Review: 8/28/2007
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