Phenothiazine Antipsychotics (cont.)

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Constipation also is common.

Phenothiazine antipsychotics can also cause neuroleptic malignant syndrome (NMS), which include symptoms of:

All phenothiazine antipsychotics carry a boxed warning of increased deaths in elderly patients when used for dementia-related psychosis.

What drugs interact with phenothiazine antipsychotics?

Phenothiazine antipsychotics should not be combined with other antipsychotics or medications that cause extra-pyramidal side effects and neuroleptic malignant syndrome due to an increased likelihood of these side effects.

Phenothiazine antipsychotics should be used with caution with medications (for example, fluoxetine [Prozac, Sarafem, Prozac Weekly]) that reduce the activity of liver enzymes that eliminate phenothiazines because levels of phenothiazines can increase and lead to more side effects.

Phenothiazines affect heart rhythm and the risk of abnormal heart rhythms, especially when they are combined with other drugs that also affect heart rhythm. Examples include:

Medically Reviewed by a Doctor on 11/18/2014

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