- What are phenothiazine antipsychotics?
- What are examples of phenothiazine antipsychotics available in the US?
- What are the side effects of phenothiazine antipsychotics?
- What drugs interact with phenothiazine antipsychotics?
- What formulations of phenothiazine antipsychotics are available?
- What about taking phenothiazine antipsychotics during pregnancy or while breastfeeding?
What are the side effects of phenothiazine antipsychotics?
There are many side effects of phenothiazine antipsychotics. Common side effects include:
Phenothiazine antipsychotics may cause extra-pyramidal symptoms such:
- as abnormal muscle contractions,
- difficulty breathing and swallowing,
- neck spasms, and
- movement abnormalities on face, arms, and legs.
Constipation also is common.
Phenothiazine antipsychotics can also cause neuroleptic malignant syndrome (NMS), which include symptoms of:
- muscle rigidity,
- altered mental status,
- irregular blood pressure, and
- irregular heart rate and rhythm.
What drugs interact with phenothiazine antipsychotics?
Phenothiazine antipsychotics should not be combined with other antipsychotics or medications that cause extra-pyramidal side effects and neuroleptic malignant syndrome due to an increased likelihood of these side effects.
Phenothiazine antipsychotics should be used with caution with medications (for example, fluoxetine [Prozac, Sarafem, Prozac Weekly]) that reduce the activity of liver enzymes that eliminate phenothiazines because levels of phenothiazines can increase and lead to more side effects.
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