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- What are phenothiazine antipsychotics?
- What are examples of phenothiazine antipsychotics available in the US?
- What are the side effects of phenothiazine antipsychotics?
- What drugs interact with phenothiazine antipsychotics?
- What formulations of phenothiazine antipsychotics are available?
- What about taking phenothiazine antipsychotics during pregnancy or while breastfeeding?
What are the side effects of phenothiazine antipsychotics?
There are many side effects of phenothiazine antipsychotics. Common side effects include:
Phenothiazine antipsychotics may cause extra-pyramidal symptoms such:
- as abnormal muscle contractions,
- difficulty breathing and swallowing,
- neck spasms, and
- movement abnormalities on face, arms, and legs.
Constipation also is common.
Phenothiazine antipsychotics can also cause neuroleptic malignant syndrome (NMS), which include symptoms of:
- muscle rigidity,
- altered mental status,
- irregular blood pressure, and
- irregular heart rate and rhythm.
What drugs interact with phenothiazine antipsychotics?
Phenothiazine antipsychotics should not be combined with other antipsychotics or medications that cause extra-pyramidal side effects and neuroleptic malignant syndrome due to an increased likelihood of these side effects.
Phenothiazine antipsychotics should be used with caution with medications (for example, fluoxetine [Prozac, Sarafem, Prozac Weekly]) that reduce the activity of liver enzymes that eliminate phenothiazines because levels of phenothiazines can increase and lead to more side effects.
- amiodarone (Cordarone),
- fluconazole (Diflucan),
- itraconazole (Sporanox),
- nortriptyline (Pamelor, Aventyl), and
- many other drugs.
Report Problems to the Food and Drug Administration
You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.
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