phenazopyridine (Uristat, UTI Relief, and others) (cont.)

Pharmacy Author:
Medical and Pharmacy Editor:

PRESCRIBED FOR: Phenazopyridine is used to provide relief of symptoms associated with lower urinary tract infections including urinary burning, pain, urgency, and frequency among others.


  • Urinary analgesic: The usual recommended adult dose is 100 to 200 mg three times daily after meals. Treatment should not exceed 2 days when used in-combination with an antibacterial agent. The maximum daily dose for adults is 600 mg.
  • Dose adjustment may be required for patients who have kidney disease. Phenazopyridine should not be used in patients whose creatinine clearance is less than 50 ml/min. Phenazopyridine should be administered every 8-16 hours in patients whose creatinine clearance is between 50-80 ml/min.
  • The usual recommended dose for children and adolescents is 4 mg/kg orally three times daily after meals. The child's pediatric doctor should calculate the dose. Treatment should not exceed 2 days when used in-combination with an antibacterial agent.

DRUG INTERACTIONS: No clinical significant drug interactions have been reported with phenazopyridine use.

PREGNANCY: Phenazopyridine is classified as FDA pregnancy risk category B (animal studies show no harm to fetuses but there are no well-controlled studies in pregnant women). Reproduction studies in rats at doses up to 50 mg/kg//day have shown no evidence of fetal harm. However, as with all drugs, phenazopyridine should be used in pregnancy only if clearly needed.

NURSING MOTHERS: It is not known if phenazopyridine is excreted in breast milk.

SIDE EFFECTS: Common side effects of phenazopyridine treatment affecting up to 10 percent of patients are headache, dizziness, and stomach cramps.

Rare but serious side effects associated with phenazopyridine (occurring in <1%) include acute kidney failure, hemolytic anemia, hepatitis (liver injury), and methemoglobinemia.

REFERENCE: FDA Prescribing Information.

Medically Reviewed by a Doctor on 11/14/2014

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