phenazopyridine (Uristat, UTI Relief, and others)

  • Pharmacy Author:
    Omudhome Ogbru, PharmD

    Dr. Ogbru received his Doctorate in Pharmacy from the University of the Pacific School of Pharmacy in 1995. He completed a Pharmacy Practice Residency at the University of Arizona/University Medical Center in 1996. He was a Professor of Pharmacy Practice and a Regional Clerkship Coordinator for the University of the Pacific School of Pharmacy from 1996-99.

  • Medical and Pharmacy Editor: Charles Patrick Davis, MD, PhD
    Charles Patrick Davis, MD, PhD

    Charles Patrick Davis, MD, PhD

    Dr. Charles "Pat" Davis, MD, PhD, is a board certified Emergency Medicine doctor who currently practices as a consultant and staff member for hospitals. He has a PhD in Microbiology (UT at Austin), and the MD (Univ. Texas Medical Branch, Galveston). He is a Clinical Professor (retired) in the Division of Emergency Medicine, UT Health Science Center at San Antonio, and has been the Chief of Emergency Medicine at UT Medical Branch and at UTHSCSA with over 250 publications.

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Dose adjustment may be required for patients who have kidney disease. Phenazopyridine should not be used in patients whose creatinine clearance is less than 50 ml/min. Phenazopyridine should be administered every 8-16 hours in patients whose creatinine clearance is between 50-80 ml/min.

The usual recommended dose for children and adolescents is 4 mg/kg orally three times daily after meals. The child's pediatric doctor should calculate the dose. Treatment should not exceed 2 days when used in-combination with an antibacterial agent.

DRUG INTERACTIONS: No clinical significant drug interactions have been reported with phenazopyridine use.

PREGNANCY: Phenazopyridine is classified as FDA pregnancy risk category B (animal studies show no harm to fetuses but there are no well-controlled studies in pregnant women). Reproduction studies in rats at doses up to 50 mg/kg//day have shown no evidence of fetal harm. However, as with all drugs, phenazopyridine should be used in pregnancy only if clearly needed.

NURSING MOTHERS: It is not known if phenazopyridine is excreted in breast milk.

SIDE EFFECTS: Common side effects of phenazopyridine treatment affecting up to 10 percent of patients are:

Rare but serious side effects associated with phenazopyridine (occurring in <1%) include:

REFERENCE: FDA Prescribing Information.

Medically Reviewed by a Doctor on 11/24/2014

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Urinary Tract Infections (Bladder Infection): UTI Symptoms, Treatment, Causes
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