What is phenazopyridine-oral, and how does it work (mechanism of action)?

Phenazopyridine is an oral urinary analgesic (pain relieving medication). It is available over-the-counter (without a prescription or OTC) in lower strengths, and with a prescription for higher strengths. It is used commonly to treat symptoms of pain, burning, urgency, frequency, and other symptoms associated with lower urinary tract infections (UTIs).

Although the exact mechanism of action is unknown, phenazopyridine is thought to provide relief of symptoms of UTIs by acting as a local anesthetic on the lining of the urinary tract. Phenazopyridine is excreted in the urine and may cause urine to change to an orange or red color. Phenazopyridine does not have any antibacterial action and should not be used to treat UTIs. It is only used to provide relief of symptoms associated with UTIs.

What brand names are available for phenazopyridine-oral?

Baridium, Pyridium, Urinary Pain Relief

Is phenazopyridine-oral available as a generic drug?

GENERIC AVAILABLE: Yes

Do I need a prescription for phenazopyridine-oral?

Yes, and in OTC preparations

What are the uses for phenazopyridine-oral?

Phenazopyridine is used to provide relief of symptoms associated with lower urinary tract infections including urinary burning, pain, urgency, and frequency among others.

What are the side effects of phenazopyridine-oral?

Common side effects of phenazopyridine treatment affecting up to 10 percent of patients are:

• headache,
• dizziness, and
• stomach cramps.

Rare but serious side effects associated with phenazopyridine (occurring in <1%) include:

• acute kidney failure,
• hemolytic anemia,
• hepatitis (liver injury), and
• methemoglobinemia.

Quick GuideBladder Infections: UTI Causes, Symptoms, Treatments

Report Problems to the Food and Drug Administration

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.