(Curvature of the Penis)
What is Peyronie's disease?
Peyronie's disease (also termed Peyronie disease) is the development of scar
tissue inside the penis that causes the penis to develop abnormal curvature
(contracture) in the scarred area. The disease may occur in about 1% to 8% of men,
most frequently in men aged about 40 to 70 years old. It can occasionally occur
in younger men.
What causes Peyronie's disease?
The exact cause of Peyronie's disease is not known. However, whatever can
cause plaque or scar formation in the penile shaft is a likely causal candidate.
Researchers have suggested several possible agents such as vitamin E deficiency,
beta-blocking medications, elevations in serotonin, and
genetic causes. Some
researchers think that minor vascular traumas to the penis (during sex or
athletic endeavors) that may reoccur over time may lead to scar formation. None
of these possible agents or processes is proven to be the cause to date.
What are the symptoms of Peyronie's disease?
The symptoms of Peyronie's disease usually are a combination of one or more
symptoms as follows:
- Unusual angulation of the penile shaft
(either when flaccid or erect or both)
- Pain during erections and/or during sex
- Scarring or plaque palpated at the
abnormal bend or angle of the penis
- An indentation of the penis shaft at
the site of the plaque or scarring
- Erectile dysfunction
- Inability to have intercourse
There are, in general, two phases of the disease. The acute phase lasts about
18 to 24 months and usually has the highest pain component; the chronic phase
(begins at about 18 to 24 months after first symptoms) usually has less pain but
in this stage, the plaque or scarring is more refractory to treatment (see
below) and may begin to develop large calcium deposits (calcified plaque or
Medically Reviewed by a Doctor on 10/1/2013
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