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- What is perphenazine, and how does it work (mechanism of action)?
- What brand names are available for perphenazine?
- Is perphenazine available as a generic drug?
- Do I need a prescription for perphenazine?
- What are the side effects of perphenazine?
- What is the dosage for perphenazine?
- Which drugs or supplements interact with perphenazine?
- Is perphenazine safe to take if I'm pregnant or breastfeeding?
- What else should I know about perphenazine?
What is perphenazine, and how does it work (mechanism of action)?
Perphenazine is an oral antipsychotic medication used for the management of schizophrenia. Perphenazine is one of the older, first-generation antipsychotic medications. Examples of other first-generation antipsychotics include:
- prochlorperazine (Compazine, Compro, Procomp)
- chlorpromazine (Promapar, Thorazine)
- trifluoperazine (Stelazine)
- thioridazine (Mellaril)
Although the exact mechanism of antipsychotics is unknown, scientists believe that they may work by blocking the action of dopamine in the brain. Dopamine is a neurotransmitter (chemical) that nerves use to communicate with one another. Perphenazine is used when patients do not respond to other antipsychotics.
What brand names are available for perphenazine?
Is perphenazine available as a generic drug?
GENERIC AVAILABLE: Yes
Do I need a prescription for perphenazine?
What are the side effects of perphenazine?
Perphenazine causes extrapyramidal side effects such as:
- Abnormal muscle contractions
- Difficulty breathing and swallowing
- Neck spasms
Other side effects include:
- Low blood pressure
- Dry mouth
- Blurred vision
- Urinary retention
- Worsening of glaucoma
- Increased or decreased blood glucose
- Tardive dyskinesia and neuroleptic malignant syndrome can result from perphenazine treatment. These side effects can be severe so patients must seek medical help.
Quick GuideSchizophrenia: Symptoms, Types, Causes, Treatment
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