GENERIC NAME: perphenazine
BRAND NAME: N/A
DISCONTINUED BRAND: Trilafon
DRUG CLASS AND MECHANISM: Perphenazine is an oral antipsychotic medication used for the management of schizophrenia. Perphenazine is one of the older, first-generation antipsychotic medications. Examples of other first-generation antipsychotics include:
- prochlorperazine (Compazine, Compro, Procomp)
- chlorpromazine (Promapar, Thorazine)
- trifluoperazine (Stelazine)
- thioridazine (Mellaril)
Although the exact mechanism of antipsychotics is unknown, scientists believe that they may work by blocking the action of dopamine in the brain. Dopamine is a neurotransmitter (chemical) that nerves use to communicate with one another. Perphenazine is used when patients do not respond to other antipsychotics.
SIDE EFFECTS WARNING:
- Long-term use of perphenazine may lead to a potentially irreversible condition called tardive dyskinesia (involuntary movements of the jaw, lips, and tongue).
- A potentially fatal complex referred to as neuroleptic malignant syndrome has been reported with anti-psychotic drugs, including perphenazine. Patients who develop this syndrome may have:
- Elderly patients with dementia-related psychosis treated with antipsychotics are at an increased risk of death, and perphenazine should not be used for treating patients with dementia-related psychosis.
- Perphenazine may impair the mental and physical abilities required for to drive a car or operate machinery.
- Like other antipsychotics neuroleptic malignant syndrome (NMS) may occur.
- Life threatening abnormal heartbeats (arrhythmias) may occur.
- Perphenazine may cause low blood pressure.
- A decrease in blood cell counts has been reported during treatment with perphenazine. Low white blood cell counts may increase the risk for infection.
- Perphenazine may increase blood levels of prolactin, a hormone that may cause women to develop a breast discharge and for men to develop breasts.
- Perphenazine may increase the risk of seizures.
Quick GuideSchizophrenia: Symptoms, Types, Causes, Treatment
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