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February 10, 2012

Patient Discussions: Pernicious Anemia - Symptoms At Onset Of Disease

Question:The symptoms of pernicious anemia can vary greatly from patient to patient. What were your symptoms at the onset of your disease?

Published: June 13

I suffered from iron deficiency originally, then I had a split mouth, sore tongue and my hair started to go grey and I was only 30. Went to the Doctors who sent me staright for blood tests and came back that I had pernicious anemia, I had heard of it so from then on I had B12 injections and that was 28 years ago. Since them my mother was diagnosed with it. I also have an underactive thyroid which was diagnosed 8 years ago.

Published: June 12

Initially I was extremely tired with tingling and numbness in my hands and feet. My physician linked the numbness and tingling to my spinal chord injury and the fatigue to a bleeding disorder I had at the time. I went to the ER for dizziness and fainting. That is when they ran tests and found that I had b12 deficiency. Initially I was taking the pill everyday but my b12 levels were not getting any better. They switched me to the monthly injections. I have been giving myself the injections for 4 years now. I can tell when it is time to take my next dose because my symptoms increase.

Related Reading: fainting

Published: June 09

I was generally feeling very tired but put in down to work. I went to give blood and it was noticed that my iron level was low when I had the blood test before you donate. This was treated with ferrous sulphate. Then low level of vitamin B12 was noticed in further blood tests. I was given vitamin B12 tablets but this did not work as it was my inability to absorb it through the gut which lead to me needing to have injections. I have these every 10 weeks as feels very tired if it's done every 3 months which tends to be the time recommended.

Comment from: David Sydney Dallime, 65-74 Male (Patient) Published: August 14

I have chronic systemic inflammatory disease evidenced by Graves Disease, Crones Disease, Chronic Bronchitis and Asthma. Do to tiredness, numbing of extremities and bloating my Doctor did a CBC which indicated anemia. Now in the care of a Hematologist I am receiving weekly vitamin B injections and taking B1-6-12 pills plus Foliamin pills.

Related Reading: Chronic Bronchitis | Asthma

Published: July 16

In January, I noticed increased fatigue, numbness and tingling. My doctor diagnosed pernicious anemia in late May and prescribed B12 injections one time a month. It makes me feel good for about five days, then I start to decline again.


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Pernicious Anemia - Treatments Question: What was the effective treatment for you pernicious anemia?

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Suggested Reading on Pernicious Anemia by Our Doctors

  • Related Diseases & Conditions

    • Anemia
      • Anemia is the condition of having less than the normal number of red blood cells or less than the normal quantity of hemoglobin in the blood. The oxygen-carrying capacity of the blood is, therefore, decreased.
    • Stomach Cancer
      • Though the cause of stomach cancer is unknown, risk factors for stomach cancer include diet, H. pylori infection, smoking age, gastritis, stomach surgery, family history, and pernicious anemia. Symptoms include stomach discomfort, feeling full after a small meal, nausea and vomiting, and weight loss. Treatment depends upon staging and may involve surgery, radiation therapy, or chemotherapy.
    • Dementia
      • Dementia is a significant loss of intellectual abilities such as memory capacity, severe enough to interfere with social or occupational functioning. There are different criteria classification schemes for dementias such as cortical, subcortical, progressive, primary, and secondary dementias. Other conditions and medication reactions can also cause dementia. Dementia is diagnosed based on a certain set of criteria. Treatment for dementia is generally focused on the symptoms of the disease.
    • Vitiligo
      • Vitiligo is a condition in which the skin turns white due to the loss of pigment from the melanocytes, cells that produce the pigment melanin that gives the skin color.
    • Thrombocytopenia (Low Platelet Count)
      • Thrombocytopenia refers to a decreased number of platelets in the blood. There are many causes of thrombocytopenia such as decreased platelet production (viral infections for example rubella, mumps, chickenpox, hepatitis C, and HIV); increased platelet destruction or consumption (for example sulfonamide antibiotics, heparin, blood transfusions, and lupus); or increased splenic sequestration (enlarged spleen due to conditions for example liver disease, blood cancers, and more). Treatment of thrombocytopenia depends on the cause.
    • Gastritis
      • Gastritis is an inflammation of the stomach lining. Causes of gastritis include drinking too much alcohol, medications such as NSAIDs, ibuprofen, aspirin, H. pylori infection, severe infections, burns, anemia, and autoimmune disorders. Gastritis is diagnosed with endoscopy, blood tests, or stool tests. Treatment depends upon the cause of gastritis.
    • Birthmark
      • Birthmarks and other abnormal skin pigmentation is caused by the body's inability to produce enough melanin. Abnormal skin pigmentation can cause conditions such as vitiligo, pigmentation loss, melasma, albinism, port wine stains, macular stains and hemangioma.
    • Graves' Disease
      • Graves' disease is an autoimmune disease that affects the thyroid. Some of the symptoms of Graves' disease include hand tremors, rapid heartbeat, trouble sleeping, enlarged thyroid, thinning of the skin or fine brittle hair. Causes of Graves' disease are thought to be multifactorial such as genes, gender, stress, and infection. Treatment for Graves' disease is generally medication.
    • Iron Deficiency
      • Iron is a mineral our bodies need. Iron deficiency is a condition resulting from not enough iron in the body. It is the most common nutritional deficiency and the leading cause in the US. Iron deficiency is caused due to increased iron deficiency from diseases, nutritional deficiency, or blood loss and the body's inability to intake or absorb iron. Children, teen girls, pregnant women, and babies are at most risk for developing iron deficiency. Symptoms of iron deficiency include feeling weak and tired, decreased work or school performance, slow social development, difficulty maintaining body temperature, decreased immune function, and an inflamed tongue. Blood tests can confirm an iron deficiency in an individual. Treatment depends on the cause of the deficiency. Proper diet that includes recommended daily allowances of iron may prevent some cases of iron deficiency.
    • Prevention
      • Enjoying a healthy diet helps to prevent diseases. A good diet also helps to control celiac disease, diabetes, and high blood pressure and maintain health by preventing loss of bone mass, muscle strength, and vitamin deficiencies.
    • Stiff-Person Syndrome
      • Stiff-Person syndrome is a neurological disorder associated with features of an autoimmune disease. Signs and symptoms of Stiff-Person syndrome include a heightened sensitivity to stimuli (noise, touch, emotional distress) and fluctuating muscle rigidity of the trunk and limbs. Conditions associated with Stiff-Person syndrome include thyroiditis, vitiligo, pernicious anemia, and diabetes. Treatment for Stiff-Person syndrome is generally medication to control symptoms.
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