I took methotrexate for a brief period - three weeks, five mg a week for sarcoidosis. After the third dose, I developed horrible burning pain in my arms from my neck into my hands. It was the worst pain I have ever had. The attack lasted almost a month. I still have numbness, pins and needles and tingling in my arms, hands and bottom of my feet. The doctor said "you won't even know you're taking it since the dose is so low." Don't take it, its poison!

I was diagnosed with peripheral neuropathy a few years ago; I had been unable to eat or drink anything for three weeks, was essentially bedridden during that time and could no longer stand up. My weight dropped from 150 to 99 lbs in those three weeks, finally giving in and calling an ambulance. Three years later, I still have some numbness in my feet, and am still unable to drive, although I can now walk and generally function better.

I have a burning sensation in several toes in my left foot. Its like little sharp jabs as if someone was sticking a pin in my toe. I do have diabetes 2 and have been on medication for several months now.

I have a severe burning sensation near and around my ankle. It is the same leg where I had deep venous thrombosis.

I was diagnosed two years ago with peripheral neuropathy in my feet and legs. Doctors suggested it was brought on by trauma: deep sores that appeared on the outside of both of my ankles after an unintentional overdose of Ambien, ambulance transport and subsequent hospitalization - I believe the sores were caused by paramedics strapping me down to the gurney, but since I was unconscious, I have no proof that this occurred. In any event, I have PN and the pain has severely increased over two year's time. Worse than the pain is the accompanying untreated depression. I am 63 years old. I do not want to live with these conditions. The depression worsens by the day. No amount or types of psychiatric medications have helped the pain of PN or the depression. I want to give up but haven't yet.

I suffer from, sudden awakenings of leg cramps. These cramps are extremely painful. They will come on in my sleep after I've been asleep for about two hours. Once the first cramp hits my leg; I will normally write off any kind of useful sleep. Very hot baths will sometimes stop these cramps; but only for short periods. Makes me hate the thought of lying down at night. I would never sleep again if it would stop the cramps forever.

My husband suffers from PN that started several years ago. He is not diabetic, and the cause has never been determined. He suspects the cause may be from exposure to Agent Orange while serving in Vietnam in 1967. It has gradually gotten worse, especially in his hands and small motor functions.

I have severe discoloration of my feet and ankles and a burning pain that sometimes reaches to my mid calf. It mostly happens when I am in bed asleep. I have been diagnosed with Sensory Peripheral Neuropathy.