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February 7, 2012
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Peripheral Neuropathy

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What is a peripheral neuropathy?

Peripheral neuropathy is disorder of nerve(s) apart from the brain and spinal cord. Patients with peripheral neuropathy may have tingling, numbness, unusual sensations, weakness, or burning pain.

What causes a peripheral neuropathy?

There are many possible causes of peripheral neuropathy, including:

  1. Diabetes Mellitus

  2. Shingles (post herpetic neuralgia)

  3. Vitamin deficiency, particularly B12 and folate

  4. Alcohol

  5. Autoimmune diseases, including lupus, rheumatoid arthritis or Guillain-Barre syndrome

  6. AIDS, whether from the disease or its treatment, syphilis, and kidney failure

  7. Inherited disorders, such as amyloid polyneuropathy or Charcot-Marie-Tooth disease

  8. Exposure to toxins, such as heavy metals, gold compounds, lead, arsenic, mercury, and organophosphate pesticides

  9. Cancer therapy drugs such as vincristine (Oncovin, Vincasar), and other medications [for example antibiotics such as metronidazole (Flagyl), and isoniazid (Nydrazid, Laniazid)]

While diabetes and post herpetic neuralgia are the most common causes of peripheral neuropathy, often times no cause is found. In these situations, it is referred to as idiopathic peripheral neuropathy.

Sometimes, peripheral nerve entrapments, such as carpal tunnel syndrome, are considered peripheral neuropathies. In these cases, pressure on the nerve rather than a disease state leads to nerve malfunction.



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Peripheral Neuropathy

What is Guillain-Barré syndrome?

Guillain-Barré syndrome is a disorder in which the body's immune system attacks part of the peripheral nervous system. The first symptoms of this disorder include varying degrees of weakness or tingling sensations in the legs. In many instances the weakness and abnormal sensations spread to the arms and upper body. These symptoms can increase in intensity until certain muscles cannot be used at all and, when severe, the patient is almost totally paralyzed. In these cases the disorder is life threatening - potentially interfering with breathing and, at times, with blood pressure or heart rate - and is considered a medical emergency. Such a patient is often put on a respirator to assist with breathing and is watched closely for problems such as an abnormal heart beat, infections, blood clots, and high or low blood pressure. Most patients, however, recover from even the most severe cases of Guillain-Barré...

Read the Guillain-Barre Syndrome article »







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