Peripheral Blood Stem Cell Transplantation

What is peripheral blood stem cell transplantation?

Peripheral blood stem cell transplantation is a new technique in which stem cells are obtainedfrom a patient's blood and used in bone marrow transplantation.

What are stem cells?

Stem cells are small, round cells with a squat nucleus and scant surrounding cytoplasm. Although unremarkable in appearance, stem cells can perform what have been called "acts of biological resurrection."

What do stem cells do?

Whereas other types of cells in the body have a limited lifespan and die after dividing their endowed number of times, a stem cell can reproduce forever. The stem cell is immortal (in cellular terms). A stem cell can forgo immortality and differentiate. By doing so, it can turn into an ordinary blood cell, like a red blood cell (an erythrocyte), a white blood cell (a leukocyte), or a large cell (a megakaryocyte) that fragments into the platelets needed for blood to clot.

What is the value of stem cells for transplantation?

A relatively small number of stem cells can miraculously repopulate the whole bone marrow, provide an endless supply of stem cells, reconstitute the entire repertory of blood cells, and restore that portion of the immune system.

Where do the stem cells come from for transplantation?

Under normal circumstances, stem cells are rarely seen in the blood stream. To recruit enough stem cells into the blood, stem cells are lured out of the bone marrow by a special regimen of drugs and thereby coaxed into entering the peripheral blood (the blood stream).

Medically Reviewed by a Doctor on 2/28/2014