pentoxifylline, Trental, Pentoxil (cont.)
Omudhome Ogbru, PharmD
Omudhome Ogbru, PharmD
Dr. Ogbru received his Doctorate in Pharmacy from the University of the Pacific School of Pharmacy in 1995. He completed a Pharmacy Practice Residency at the University of Arizona/University Medical Center in 1996. He was a Professor of Pharmacy Practice and a Regional Clerkship Coordinator for the University of the Pacific School of Pharmacy from 1996-99.
Medical and Pharmacy Editor:
GENERIC AVAILABLE: Yes
PREPARATIONS: Tablets: 400 mg
STORAGE: Pentoxifylline should be stored at room temperature between 15 C - 30 C (59 F - 86 F), in a light resistant container.
PRESCRIBED FOR: Pentoxifylline is used for the treatment of intermittent claudication caused by peripheral arterial disease.
DOSING: The recommended dose of pentoxifylline is 400 mg three times daily with meals. The dose may be reduced to 400 mg twice daily to reduce adverse effects.
DRUG INTERACTIONS: Pentoxifylline reduces the breakdown of theophylline (Theo-Dur, Respbid, Slo-Bid, Theo-24, Theolair, Uniphyl, Slo-Phyllin) in the liver, increasing blood levels and side effects of theophylline. Combining pentoxifylline with warfarin (Coumadin) may increase the risk of bleeding. The mechanism for this interaction is unknown.
PREGNANCY: Pentoxifylline has not been adequately studied in pregnant women.
NURSING MOTHERS: Pentoxifylline is excreted in breast milk and may cause adverse effects in the infant.
SIDE EFFECTS: Common adverse effects include nausea, vomiting, dizziness, headache, diarrhea, blurred vision, agitation, insomnia and drowsiness. Rarely, patients may experience abnormal heart beats, elevation of liver function tests, jaundice, and hepatitis.
Reference: FDA Prescribing Information
Medically Reviewed by a Doctor on 10/27/2014
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