pentoxifylline, Trental (cont.)

Pharmacy Author:
Medical and Pharmacy Editor:

PRESCRIBED FOR: Pentoxifylline is used for the treatment of intermittent claudication caused by peripheral artery disease.

DOSING: The recommended dose of Pentoxifylline is 400 mg three times daily with meals.

DRUG INTERACTIONS: Pentoxifylline reduces the breakdown of theophylline (Theo-Dur, Respbid, Slo-Bid, Theo-24, Theolair, Uniphyl, Slo-Phyllin) in the liver, increasing blood levels and side effects of theophylline. Combining pentoxifylline with warfarin (Coumadin) may increase the risk of bleeding. The mechanism for this interaction is unknown.

PREGNANCY: Pentoxifylline has not been adequately studied in pregnant women.

NURSING MOTHERS: Pentoxifylline is excreted in breast milk and may cause adverse effects in the infant.

SIDE EFFECTS: Common adverse effects include nausea, vomiting, dizziness, headache, diarrhea, blurred vision, agitation, insomnia and drowsiness. Rarely, patients may experience abnormal heart beats, elevation of liver function tests, jaundice, and hepatitis.

Reference: FDA Prescribing Information

Last Editorial Review: 3/27/2009

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