pentoxifylline, Trental

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GENERIC NAME: pentoxifylline

BRAND NAME: Trental

DRUG CLASS AND MECHANISM: Pentoxifylline is an oral drug used for treating symptoms of intermittent claudication caused by peripheral arterial disease (PAD). PAD is caused by the build-up of cholesterol plaques in arteries of the legs. Plaque blocks arteries, reducing the flow of oxygen-carrying blood through the arteries to the muscles. This causes pain upon walking and reduces mobility. PAD is similar to coronary artery disease in which plaque builds up in heart arteries, causing chest pain (angina) because of a reduced supply of oxygen to the heart's muscle. Pentoxifylline, through unknown mechanisms, decreases the "stickiness" (viscosity) of blood and thereby improves its flow through arteries. This increases the flow of blood and oxygen to muscles and helps patients with intermittent claudication. The FDA approved pentoxifylline in August 1984.

PRESCRIPTION: Yes

GENERIC AVAILABLE: Yes

PREPARATIONS: Tablets: 400 mg

STORAGE: Pentoxifylline should be stored at room temperature between 15-30 C (59- 86  F), in a light resistant container.




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