Other important side effects include abnormalities of liver tests in the blood. Bleeding from the rectum and other areas also may occur.
GENERIC AVAILABLE: No
PREPARATIONS: Capsules: 100 mg.
STORAGE: Pentosan should be stored at room temperature, between 15 C to 30 C (59 F to 86 F).
DOSING: The recommended dose of pentosan is 100 mg three times daily (every 8 hours) taken at least one hour before or two hours after meals so that food does not retard its absorption. Patients should be evaluated after 3 months, and treatment may be continued for another three months if patients have not improved and they are tolerating pentosan.
DRUG INTERACTIONS: Pentosan resembles heparin and it affects the ability of blood to clot. Therefore, it can cause bleeding and if combined with other drugs that also cause bleeding (anticoagulants) the risk of bleeding may increase. Examples of drugs that cause bleeding include heparin, streptokinase, aspirin, nonsteroidal anti-inflammatory drugs (for example, ibuprofen), and warfarin (Coumadin).
PREGNANCY: Studies with pentosan have not been conducted in pregnant women.
NURSING MOTHERS: Studies of pentosan have not been conducted in nursing mothers.
Medically reviewed by Eni Williams, PharmD
Reference: FDA Prescribing Information
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