penicillin V potassium (Beepen-VK, Penicillin VK, V-Cillin-K, Veetids) (cont.)

Medical Author:
Medical and Pharmacy Editor:

DOSING: The usual recommended dosage for adults and children 12 years and older are as follows:

Streptococcal infections: For the treatment of mild to moderately severe bacterial infections of the upper respiratory tract, scarlet fever, and cellulitis of the skin (erysipelas): 125 to 250 mg (200,000 to 400,000 unit) every 6 to 8 hours for 10 days.

Pneumococcal infections: For the treatment of mild to moderately severe bacterial infections of the respiratory tract, including otitis media (middle ear infection): 250 to 500 mg (400,000 to 800,000 units) every 6 hours until the patient has been without fever (afebrile) for at least 2 days.

Staphylococcal infections: For the treatment of mild infections of the skin and soft tissue: 250 to 500 mg (400,000 to 800,000 units) every 6 to 8 hours.

Fusospirochetosis (Vincent's infection) of the oropharynx (the part of the throat at the back of the mouth): For the treatment of mild to moderately severe bacterial infections: 250 to 500 mg (400,000 to 800,000 units) every 6 to 8 hours.

Rheumatic fever prophylaxis: 125 to 250 mg (200,000 to 400,000 units) twice daily as maintenance.

Prophylaxis against bacterial endocarditis in patients with congenital heart disease or rheumatic or other acquired heart valve disease who are undergoing dental or surgical procedures involving the upper respiratory tract: Administer 2 grams of penicillin V potassium (1 gram for children weighing < 60 pounds) 1 hour before the procedure, followed by 1 gram (500 mg for children weighing < 60 pounds) 6 hours later.

DRUG INTERACTIONS: Penicillin V potassium may inhibit the renal tubular secretion (elimination of the drug via the kidneys) of methotrexate (Trexall, Rheumatrex). Co-administration may result in higher blood levels of methotrexate and increases the risk of methotrexate toxicity (side effects).

Penicillin V potassium may interfere with the effectiveness of the live typhoid vaccine. Administration of the vaccine must be separated by at least 24 hours from the last dose of the antibiotic.

Medically Reviewed by a Doctor on 12/3/2014


Report Problems to the Food and Drug Administration

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.

Pill Finder Tool

Need help identifying pills and medications?
Use the pill identifier tool on RxList.


Back to Medications Index

Health Solutions From Our Sponsors