penicillin V potassium (Beepen-VK, Penicillin VK, V-Cillin-K, Veetids) (cont.)

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Pneumococcal infections: For the treatment of mild to moderately severe bacterial infections of the respiratory tract, including otitis media (middle ear infection): 250 to 500 mg (400,000 to 800,000 units) every 6 hours until the patient has been without fever (afebrile) for at least 2 days.

Staphylococcal infections: For the treatment of mild infections of the skin and soft tissue: 250 to 500 mg (400,000 to 800,000 units) every 6 to 8 hours.

Fusospirochetosis (Vincent's infection) of the oropharynx (the part of the throat at the back of the mouth): For the treatment of mild to moderately severe bacterial infections: 250 to 500 mg (400,000 to 800,000 units) every 6 to 8 hours.

Rheumatic fever prophylaxis: 125 to 250 mg (200,000 to 400,000 units) twice daily as maintenance.

Prophylaxis against bacterial endocarditis in patients with congenital heart disease or rheumatic or other acquired heart valve disease who are undergoing dental or surgical procedures involving the upper respiratory tract: Administer 2 grams of penicillin V potassium (1 gram for children weighing < 60 pounds) 1 hour before the procedure, followed by 1 gram (500 mg for children weighing < 60 pounds) 6 hours later.

DRUG INTERACTIONS: Penicillin V potassium may inhibit the renal tubular secretion (elimination of the drug via the kidneys) of methotrexate (Trexall, Rheumatrex). Co-administration may result in higher blood levels of methotrexate and increases the risk of methotrexate toxicity (side effects).

Penicillin V potassium may interfere with the effectiveness of the live typhoid vaccine. Administration of the vaccine must be separated by at least 24 hours from the last dose of the antibiotic.

Antibiotics such as penicillin V potassium may decrease the effectiveness of certain oral contraceptives or birth control pills. Patients may use an alternative form of birth control (for example, condoms) while on antibiotic therapy to prevent unexpected pregnancies.

Medically Reviewed by a Doctor on 12/3/2014


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