penicillin V potassium (Beepen-VK, Penicillin VK, V-Cillin-K)

  • Medical Author:
    Omudhome Ogbru, PharmD

    Dr. Ogbru received his Doctorate in Pharmacy from the University of the Pacific School of Pharmacy in 1995. He completed a Pharmacy Practice Residency at the University of Arizona/University Medical Center in 1996. He was a Professor of Pharmacy Practice and a Regional Clerkship Coordinator for the University of the Pacific School of Pharmacy from 1996-99.

  • Medical and Pharmacy Editor: Charles Patrick Davis, MD, PhD
    Charles Patrick Davis, MD, PhD

    Charles Patrick Davis, MD, PhD

    Dr. Charles "Pat" Davis, MD, PhD, is a board certified Emergency Medicine doctor who currently practices as a consultant and staff member for hospitals. He has a PhD in Microbiology (UT at Austin), and the MD (Univ. Texas Medical Branch, Galveston). He is a Clinical Professor (retired) in the Division of Emergency Medicine, UT Health Science Center at San Antonio, and has been the Chief of Emergency Medicine at UT Medical Branch and at UTHSCSA with over 250 publications.

What is the dosage for penicillin v potassium-oral solids?

The usual recommended dosage for adults and children 12 years and older are as follows:

Which drugs or supplements interact with penicillin v potassium-oral solids?

Penicillin V potassium may inhibit the renal tubular secretion (elimination of the drug via the kidneys) of methotrexate (Trexall, Rheumatrex). Co-administration may result in higher blood levels of methotrexate and increases the risk of methotrexate toxicity (side effects).

Penicillin V potassium may interfere with the effectiveness of the live typhoid vaccine. Administration of the vaccine must be separated by at least 24 hours from the last dose of the antibiotic.

Antibiotics such as penicillin V potassium may decrease the effectiveness of certain oral contraceptives or birth control pills. Patients may use an alternative form of birth control (for example, condoms) while on antibiotic therapy to prevent unexpected pregnancies.

Penicillin antibiotics may inhibit vitamin K synthesis due to their effect on the normal intestinal flora. Therefore, co-administration of warfarin (a vitamin K antagonist) with penicillin V potassium may increase the risk of bleeding.

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