Rare (occurring at frequency of <1%) but serious side effects include:
Hypersensitivity reactions have been reported with penicillin use.
GENERIC AVAILABLE: Yes
PREPARATIONS: Powder for oral solution: 125 mg/5 ml (100 ml, 200 ml); 250 mg/5 ml (100 ml, 200 ml); Tablets: 250 mg, 500 mg
STORAGE: Reconstituted product may be stored for up to 14 days and requires refrigeration 2.2 C to 7.7 C (36 F to 46 F). Un-reconstituted product and oral tablets may be stored at room temperature between 20 C to 25 C (68 F to 77 F).
DOSING: The usual recommended dosage for adults and children 12 years and older are as follows:
Streptococcal infections: For the treatment of mild to moderately severe bacterial infections of the upper respiratory tract, scarlet fever, and cellulitis of the skin (erysipelas): 125 to 250 mg (200,000 to 400,000 unit) every 6 to 8 hours for 10 days.
Pneumococcal infections: For the treatment of mild to moderately severe bacterial infections of the respiratory tract, including otitis media (middle ear infection): 250 to 500 mg (400,000 to 800,000 units) every 6 hours until the patient has been without fever (afebrile) for at least 2 days.
Staphylococcal infections: For the treatment of mild infections of the skin and soft tissue: 250 to 500 mg (400,000 to 800,000 units) every 6 to 8 hours.
Fusospirochetosis (Vincent's infection) of the oropharynx (the part of the throat at the back of the mouth): For the treatment of mild to moderately severe bacterial infections: 250 to 500 mg (400,000 to 800,000 units) every 6 to 8 hours.
Rheumatic fever prophylaxis: 125 to 250 mg (200,000 to 400,000 units) twice daily as maintenance.
Prophylaxis against bacterial endocarditis in patients with congenital heart disease or rheumatic or other acquired heart valve disease who are undergoing dental or surgical procedures involving the upper respiratory tract: Administer 2 grams of penicillin V potassium (1 gram for children weighing < 60 pounds) 1 hour before the procedure, followed by 1 gram (500 mg for children weighing < 60 pounds) 6 hours later.
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