penicillin G benzathine (Bicillin L-A) (cont.)

Pharmacy Author:
Medical and Pharmacy Editor:

Coadminstration of penicillin G benzathine with warfarin (Coumadin) may increase the risk of bleeding. Antibiotics may inhibit vitamin K synthesis and warfarin is a vitamin K antagonist (also inhibits the action of vitamin K). Patients on combination therapy should be closely monitored for signs or symptoms of bleeding.

PREGNANCY: Penicillin G benzathine has not been adequately evaluated in pregnant women. No evidence of harm has been demonstrated in animal reproduction studies. Use of penicillin products has generally not caused fetal harm when used during pregnancy. Penicillin G is the drug of choice for the treatment of syphilis during pregnancy. Penicillin G benzathine is classified as FDA pregnancy risk category B (animal reproduction studies have failed to demonstrate a risk to the fetus and there are no adequate and well – controlled studies in pregnant women).

NURSING MOTHERS: Penicillin G benzathine is excreted in human milk. Due to the lack of safety data, penicillin G benzathine should be used cautiously in females who are breastfeeding.

SIDE EFFECTS: Side effects associated with penicillin G benzathine treatment are:

REFERENCE: FDA Prescribing Information.

Medically Reviewed by a Doctor on 11/24/2014

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