penicillin G benzathine (Bicillin L-A) (cont.)
Penicillin G benzathine is also used for prevention of rheumatic fever or chorea.
DRUG INTERACTIONS: Penicillin G benzathine may decrease the renal tubular secretion (elimination via the kidneys) of methotrexate (Trexall, Rheumatrex) causing an increase in blood levels of methotrexate. Patients on combination therapy should be closely monitored for the occurrence of side effects.
Penicillin G benzathine may interfere with the body's response to the live typhoid vaccine (Vivotif Berna Vaccine). The general recommendation is to wait 24 hours or longer since the administration of the last dose of the antibiotic before administrating the vaccine.
Penicillin G benzathine may decrease the effectiveness of oral contraceptives (birth control pills). Patients may need to use a backup method of contraceptive while on antibiotic treatment.
Coadminstration of penicillin G benzathine with warfarin (Coumadin) may increase the risk of bleeding. Antibiotics may inhibit vitamin K synthesis and warfarin is a vitamin K antagonist (also inhibits the action of vitamin K). Patients on combination therapy should be closely monitored for signs or symptoms of bleeding.
Medically Reviewed by a Doctor on 11/24/2014
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