penicillin G benzathine (Bicillin L-A)

  • Pharmacy Author:
    Omudhome Ogbru, PharmD

    Dr. Ogbru received his Doctorate in Pharmacy from the University of the Pacific School of Pharmacy in 1995. He completed a Pharmacy Practice Residency at the University of Arizona/University Medical Center in 1996. He was a Professor of Pharmacy Practice and a Regional Clerkship Coordinator for the University of the Pacific School of Pharmacy from 1996-99.

  • Medical and Pharmacy Editor: Charles Patrick Davis, MD, PhD
    Charles Patrick Davis, MD, PhD

    Charles Patrick Davis, MD, PhD

    Dr. Charles "Pat" Davis, MD, PhD, is a board certified Emergency Medicine doctor who currently practices as a consultant and staff member for hospitals. He has a PhD in Microbiology (UT at Austin), and the MD (Univ. Texas Medical Branch, Galveston). He is a Clinical Professor (retired) in the Division of Emergency Medicine, UT Health Science Center at San Antonio, and has been the Chief of Emergency Medicine at UT Medical Branch and at UTHSCSA with over 250 publications.

What is penicillin g benzathine-injection, and how does it work (mechanism of action)?

Penicillin G benzathine (Bicillin L-A) is a penicillin antibiotic that is given by deep intramuscular injection. Penicillin G benzathine kills susceptible bacteria by inhibiting the synthesis or formation of bacterial cell wall. It is thought to preferentially bind to specific penicillin-binding proteins (PBPs) found inside the bacterial cell wall. The end result of the inhibition of bacterial cell synthesis is cell lysis and the death of the susceptible bacteria.

Penicillin G benzathine has poor solubility and is therefore very slowly released from the site of injection. In the blood, penicillin G benzathine is broken down to penicillin G. Penicillin G benzathine formulation is released and absorbed slowly to allow for a more prolonged duration of action (drug works slowly over an longer period of time).

What brand names are available for penicillin g benzathine-injection?

Bicillin L-A

Is penicillin g benzathine-injection available as a generic drug?

GENERIC AVAILABLE: Not available in the US

Do I need a prescription for penicillin g benzathine-injection?

Yes

What are the side effects of penicillin g benzathine-injection?

Side effects associated with penicillin G benzathine treatment are:

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