What is penicillin g benzathine-injection, and how does it work (mechanism of action)?

Penicillin G benzathine (Bicillin L-A) is a penicillin antibiotic that is given by deep intramuscular injection. Penicillin G benzathine kills susceptible bacteria by inhibiting the synthesis or formation of bacterial cell wall. It is thought to preferentially bind to specific penicillin-binding proteins (PBPs) found inside the bacterial cell wall. The end result of the inhibition of bacterial cell synthesis is cell lysis and the death of the susceptible bacteria.

Penicillin G benzathine has poor solubility and is therefore very slowly released from the site of injection. In the blood, penicillin G benzathine is broken down to penicillin G. Penicillin G benzathine formulation is released and absorbed slowly to allow for a more prolonged duration of action (drug works slowly over an longer period of time).

What brand names are available for penicillin g benzathine-injection?

Bicillin L-A

Is penicillin g benzathine-injection available as a generic drug?

GENERIC AVAILABLE: Not available in the US

Do I need a prescription for penicillin g benzathine-injection?

Yes

What are the side effects of penicillin g benzathine-injection?

Side effects associated with penicillin G benzathine treatment are:

• hypersensitivity or allergic reactions,
• upset stomach,
• neuropathy,
• cardiac or heart problems,
• dizziness,
• fatigue,
• headache,
• nervousness,
• pain,
• seizures,
• weakness,
• sexual dysfunction,
• injection site reactions,
• blurred vision,
• kidney problems, and
• others.

Quick GuideSymptoms of Mono: Infectious Mononucleosis Treatment

Report Problems to the Food and Drug Administration

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.