The absorption of penicillamine is reduced by iron (ferrous sulphate), magnesium and aluminum salts (for example, antacids) because they form unabsorbable complexes with penicillamine in the intestine. Administration of penicillamine and iron containing products or antacids should be separated by 2 hours.
PREGNANCY: Penicillamine should not be taken by pregnant women unless it is for a life-threatening condition, because of potential harm to the fetus.
NURSING MOTHERS: Penicillamine should not be used by nursing mothers because of potential adverse effects in the infant.
SIDE EFFECTS: Common reactions to penicillamine include abdominal pain, cramps, rash, allergic reactions, weight loss, diarrhea, dysgeusia (loss of sense of taste), nausea, lip swelling, itching, and vomiting.
Penicillamine can cause bone marrow suppression (anemia, low blood platelets [thrombocytopenia] and white blood cells [neutropenia]) and serious kidney disease. All patients who take penicillamine require regular blood and urine testing to monitor for these side effects.
Penicillamine can increase the requirement for vitamin B6 (pyridoxine), and supplements of pyridoxine are advised. Penicillamine has an unusual risk of inducing immune-related diseases, such as systemic lupus erythematosus, polymyositis, Goodpasture's syndrome, and myasthenia gravis.
FDA Prescribing Information
Medscape. penicillamine (Rx) - Cuprimine, Depen.
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