pemoline, Cylert

  • Pharmacy Author:

    Marilyn A. D. Yee completed her Doctor of Pharmacy degree from the University of Michigan in Ann Arbor in 1995. Dr. Yee received further training for two years in two pharmacy residencies offered by the University Of Arizona College Of Pharmacy, and the University Medical Center in Tucson, Arizona.

  • Medical and Pharmacy Editor: Jay W. Marks, MD
    Jay W. Marks, MD

    Jay W. Marks, MD

    Jay W. Marks, MD, is a board-certified internist and gastroenterologist. He graduated from Yale University School of Medicine and trained in internal medicine and gastroenterology at UCLA/Cedars-Sinai Medical Center in Los Angeles.

NOTE: March 25, 2005, pemoline (Cylert) has been withdrawn from the market because of declining sales.

GENERIC NAME: pemoline


DRUG CLASS AND MECHANISM: Pemoline is an oral drug that is used to treat attention deficit hyperactivity disorder (ADHD) as part of an overall treatment program for children with ADHD. Pemoline has effects that are similar to methylphenidate (Ritalin) which also is used to treat ADHD. Pemoline and methylphenidate both have the ability to stimulate the brain, probably by affecting neurotransmitters, the chemicals in the brain that nerves use to communicate with each other. Although both drugs are considered stimulants, they have different effects on neurotransmitters in the brain. Pemoline was approved for use by the FDA in 1975.



PREPARATIONS: Tablets: 18.75 mg, 37.5 mg and 75 mg. Chewable tablet: 37.5 mg.

STORAGE: Pemoline should be stored below 30°C(86°F).

PRESCRIBED FOR: Pemoline is used as part of a treatment program for children with ADHD. Other FDA unapproved uses include narcolepsy, fatigue, and excessive daytime sleepiness. (Narcolepsy is a chronic disease of the brain and spinal cord most commonly characterized by a recurrent, uncontrollable desire to sleep.)

DOSING: Pemoline should be taken in the morning. It may take up to three weeks to observe an effect. Doses should be reduced if poor kidney function exists.

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