peginterferon beta-1a (Plegridy)

  • Pharmacy Author:
    Omudhome Ogbru, PharmD

    Dr. Ogbru received his Doctorate in Pharmacy from the University of the Pacific School of Pharmacy in 1995. He completed a Pharmacy Practice Residency at the University of Arizona/University Medical Center in 1996. He was a Professor of Pharmacy Practice and a Regional Clerkship Coordinator for the University of the Pacific School of Pharmacy from 1996-99.

  • Medical Editor: Charles Patrick Davis, MD, PhD
    Charles Patrick Davis, MD, PhD

    Charles Patrick Davis, MD, PhD

    Dr. Charles "Pat" Davis, MD, PhD, is a board certified Emergency Medicine doctor who currently practices as a consultant and staff member for hospitals. He has a PhD in Microbiology (UT at Austin), and the MD (Univ. Texas Medical Branch, Galveston). He is a Clinical Professor (retired) in the Division of Emergency Medicine, UT Health Science Center at San Antonio, and has been the Chief of Emergency Medicine at UT Medical Branch and at UTHSCSA with over 250 publications.

What is peginterferon beta-1a plegridy, and how does it work (mechanism of action)?

Peginterferon beta-1a (Plegridy) is a protein produced by recombinant DNA technology using genetically engineered Chinese Hamster Ovary Cells into which the human interferon beta genes have been introduced. It is used for treating multiple sclerosis (MS). It differs from interferon beta-1a by having polyethylene glycol attached to the interferon molecules (peglated) that allow the interferon to remain in the body for longer times thus allowing less frequent dosing. Interferon beta-1a is designed to be identical to interferon beta that is naturally produced by various cells in the body. Interferon beta has antiviral properties and plays a role in regulating the immune response. The exact mechanism by which interferon beta-1a works in the body to treat MS is not known. Interferon beta-1a does not cure MS. Rather it helps to decrease the number of flare-ups and slows the occurrence of some of the physical disability that commonly occurs in the disease. Plegridy works in the same way and has similar side effects as other interferon beta-1a products such as Avonex and Rebif. However, it is given every 14 days versus once weekly or 3 times per week injections. The FDA approved Plegridy in August, 2014.

What brand names are available for peginterferon beta-1a plegridy?


Is peginterferon beta-1a plegridy available as a generic drug?


Do I need a prescription for peginterferon beta-1a plegridy?


What are the side effects of peginterferon beta-1a plegridy?

The most common side effects of interferon beta-1a are:

Flu-like symptoms are commonly experienced when patients first start taking interferon beta-1a. These symptoms can be managed with over-the-counter pain and fever reducers, and usually decrease or go away over time.

Stomach pain, an increase in liver enzymes, and blood disorders including a drop in the number of red blood cells, white blood cells, and platelets also occur.

Interferon beta-1a may also cause other serious side effects including seizures, suicidal thoughts or actions, liver disease, and serious allergic and skin reactions.

Quick GuideMultiple Sclerosis (MS) Symptoms and Treatment

Multiple Sclerosis (MS) Symptoms and Treatment
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