paroxetine (cont.)
Paroxetine may increase the effect of the blood thinner,
warfarin (Coumadin), leading to excessive bleeding. Therefore, warfarin therapy should be
monitored more frequently in patients who are also taking paroxetine. Combining
SSRIs such as paroxetine with aspirin, nonsteroidal anti-inflammatory drugs or
other drugs that affect bleeding may increase the likelihood of upper
gastrointestinal
bleeding. Phenytoin (Dilantin) and phenobarbital may decrease the amount of
paroxetine in the body and possibly reduce its effectiveness.
PREGNANCY: Use of paroxetine
during pregnancy may result in congenital heart defects. Paroxetine should not
be administered to pregnant women unless
the need justifies the risk.
NURSING MOTHERS: Paroxetine
is secreted in breast milk. Mothers who are taking paroxetine should consider
not breastfeeding.
SIDE EFFECTS: Paroxetine can
cause nausea,
headaches, anxiety, insomnia, drowsiness, constipation, weakness,
dry mouth, sweating, diarrhea and loss of appetite. Increased blood pressure can
occur, and blood pressure should be monitored during treatment.
Seizures have
been reported. Sexual dysfunction
has been associated with paroxetine. Some patients may experience withdrawal
reactions upon stopping paroxetine. Symptoms of withdrawal include anxiety,
nausea, nervousness, and insomnia. The dose of paroxetine should be gradually
reduced when therapy is discontinued.
Antidepressants increased the risk of suicidal thinking
and behavior (suicidality) in short-term studies in children and adolescents
with depression and other psychiatric disorders. Anyone considering the use of paroxetine or any
other antidepressant in a child or adolescent must balance this risk with the
clinical need. Patients who are started on therapy should be closely observed
for clinical worsening, suicidality, or unusual changes in behavior.
Reference: FDA Prescribing Information
Last Editorial Review: 11/26/2008
Report Problems to the Food and Drug Administration
You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.
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