pantoprazole, Protonix (cont.)

Pharmacy Author:
Medical and Pharmacy Editor:

SIDE EFFECTS: Pantoprazole like other PPIs is well-tolerated. The most common side effects are:

Rare side effects include:

High doses and long-term use (1 year or longer) of pantoprazole may increase the risk of osteoporosis-related fractures of the hip, wrist, or spine. Therefore, it is important to use the lowest doses and shortest duration of treatment necessary for the condition being treated.

Proton pump inhibitors may increase the risk of Clostridium difficile infection. High doses and long-term use (1 year or longer) may increase the risk of osteoporosis-related fractures of the hip, wrist, or spine. Prolonged use also reduces absorption of vitamin B12 (cyanocobalamin).

Long-term use of PPIs has also been associated with low levels of magnesium (hypomagnesemia). Analysis of patients taking PPIs for long periods of time showed an increased risk of heart attacks.

Therefore, it is important to use the lowest doses and shortest duration of treatment necessary for the condition being treated.

Medically Reviewed by a Doctor on 7/13/2015


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