Pantethine

• What other names is Pantethine known by?
• What is Pantethine?
• How does Pantethine work?
• Are there safety concerns?
• Are there any interactions with medications?
• Dosing considerations for Pantethine.

What other names is Pantethine known by?

Bis-pantothenamidoethyl disulfide, D-bis-(N-Pantothenyl-B-aminoethyl)-disulfide, D-Pantethine, D-Pantéthine, Pantéthine, Pantetheine, Pantethine Octahydrate, Pantetina, Pantomin, Pantosin.

What is Pantethine?

Pantethine is a dietary supplement that is related to vitamin B5 (pantothenic acid).

Pantethine is used for lowering cholesterol, preventing inflammation, boosting the activity of the immune system, treating an inherited condition called cystinosis, treating gastrointestinal (GI) diseases, and improving athletic performance. It is also used for improving energy, lowering the risk of heart attack and stroke, improving adrenal function, protecting against mental and physical stress, and preventing allergy symptoms in people who are allergic to formaldehyde.

Possibly Effective for...

• Lowering blood fats such as cholesterol and triglycerides, but only modestly. While not all research findings agree, taking pantethine by mouth or as a shot might slightly lower triglycerides, total cholesterol, and "bad" low-density lipoprotein (LDL) cholesterol; as well as raise "good" high-density lipoprotein (HDL) cholesterol. Pantethine also appears to correct blood fat problems that often occur in kidney failure patients who are undergoing hemodialysis.

Insufficient Evidence to Rate Effectiveness for...

• Athletic performance. Some research suggests that taking pantethine in combination with pantothenic acid and thiamine (given as allithiamin) does not improve muscular strength or endurance in well-trained athletes.
• Treating cystinosis, an inherited disease. Early research suggests that pantethine might be beneficial for cystinosis.
• Reducing risk of heart and circulatory disease.
• Improving function of the adrenal gland.
• Preventing allergy symptoms in people allergic to formaldehyde.
• Other conditions.

More evidence is needed to rate the effectiveness of pantethine for these uses.

Natural Medicines Comprehensive Database rates effectiveness based on scientific evidence according to the following scale: Effective, Likely Effective, Possibly Effective, Possibly Ineffective, Likely Ineffective, and Insufficient Evidence to Rate (detailed description of each of the ratings).