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GENERIC NAME: PANCRELIPASE - ORAL ENTERIC COATED CAPSULE (pan-kreh-LIP-aze)

BRAND NAME(S): Cotazym-S, Creon, Pancrease, Pancron, Protilase, Ultrase, Zymase

Medication Uses | How To Use | Side Effects | Precautions | Drug Interactions | Overdose | Notes | Missed Dose | Storage

USES: This medication contains digestive enzymes which help digest and absorb foods. It is used to treat symptoms of pancreatitis or other various digestive disorders.

HOW TO USE: This medication works best if taken with or after meals. Swallow the capsule whole. Do not crush or chew it. The capsule may also be opened, the contents sprinkled on a small amount of soft food (e.g., gelatin, applesauce) and the food swallowed immediately without chewing. Do not mix the contents of the capsule with alkaline foods such as milk or ice cream because the protective coating may dissolve prematurely. Antacids may hinder the effects of this medication. Do not take an antacid at the same time as this medication. Wait at least two hours between administration.

SIDE EFFECTS: Generally this medication is very well tolerated and side effects are mild if they occur. Diarrhea, cramping or stomach upset may occur when starting treatment. If these effects persist or worsen, inform your doctor. Although very unlikely to occur, notify your doctor if you develop: a skin rash, severe stomach distress. If you notice other effects not listed above, contact your doctor or pharmacist.

PRECAUTIONS: Tell your doctor your medical history, especially of: allergies (especially to pork). This medication should be used during pregnancy only if clearly needed. Discuss the risks and benefits with your doctor. It is not known if this medication appears in breast milk. Consult your doctor before breast-feeding.

DRUG INTERACTIONS: Tell your doctor of all prescription and nonprescription medication you may use. Do not start or stop any medicine without doctor or pharmacist approval.




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You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.


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pancrelipase-oral enteric coated capsule, Cotazym-S, Creon, Pancrease, Pancron, Protilase, Ultr

What is pancreatitis?

Pancreatitis is an inflammation of the pancreas. The pancreas is a large gland behind the stomach and close to the duodenum. The duodenum is the upper part of the small intestine. The pancreas secretes digestive enzymes into the small intestine through a tube called the pancreatic duct. These enzymes help digest fats, proteins, and carbohydrates in food. The pancreas also releases the hormones insulin and glucagon into the bloodstream. These hormones help the body use the glucose it takes from food for energy.

Normally, digestive enzymes do not become active until they reach the small intestine, where they begin digesting food. But if these enzymes become active inside the pancreas, they start "digesting" the pancreas itself.

Acute pancreatitis occurs suddenly and lasts for a short period of time and usually resolves. Chronic pancreatitis does not resolve itself and results in a slow destruction of t...

Read the Pancreatitis article »



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