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- What is paliperidone palmitate Invega Sustenna, and how does it work (mechanism of action)?
- What brand names are available for paliperidone palmitate Invega Sustenna?
- Is paliperidone palmitate Invega Sustenna available as a generic drug?
- Do I need a prescription for paliperidone palmitate Invega Sustenna?
- What are the side effects of paliperidone palmitate Invega Sustenna?
- What is the dosage for paliperidone palmitate Invega Sustenna?
- Which drugs or supplements interact with paliperidone palmitate Invega Sustenna?
- Is paliperidone palmitate Invega Sustenna safe to take if I'm pregnant or breastfeeding?
- What else should I know about paliperidone palmitate Invega Sustenna?
What is paliperidone palmitate Invega Sustenna, and how does it work (mechanism of action)?
- olanzapine (Zyprexa),
- quetiapine (Seroquel),
- ziprasidone (Geodon),
- iloperidone (Fanapt),
- asenapine (Saphris) and
- aripiprazole (Abilify).
Atypical antipsychotics differ from typical antipsychotics because they cause a lesser degree of movement (extrapyramidal) side effects and constipation.
The exact mechanism of action of paliperidone is not known, but, like other anti-psychotics, it is believed that paliperidone affects the way the brain works by interfering with communication among the brain's nerves. Nerves communicate with each other by making and releasing chemicals called neurotransmitters. The neurotransmitters travel to other nearby nerves where they attach to receptors on the nerves. The attachment of the neurotransmitters either stimulates or inhibits the function of the nearby nerves. Paliperidone blocks several of the receptors on nerves including dopamine type 2, serotonin type 2, and alpha 2 adrenergic receptors. It is believed that many psychotic illnesses are caused by abnormal communication among nerves in the brain and that by altering communication through neurotransmitters, paliperidone can alter the psychotic state. Invega Sustenna was approved by the FDA in July 2009.
What brand names are available for paliperidone palmitate Invega Sustenna?
Is paliperidone palmitate Invega Sustenna available as a generic drug?
GENERIC AVAILABLE: No
Do I need a prescription for paliperidone palmitate Invega Sustenna?
What are the side effects of paliperidone palmitate Invega Sustenna?
The most common side effects include
- injection site reaction,
- weight gain,
- upper respiratory tract infection,
- feeling restlessness or difficulty sitting still,
- stiffness and shuffling walk,
- tremors, and
- slow movements.
Less common but serious side effects include:
- Increased risk of stroke in elderly patients with dementia-related psychosis.
- Neuroleptic malignant syndrome (NMS). NMS is a rare but serious side effect associated with the use of antipsychotics. NMS may result in death and must be treated in the hospital. Signs and symptoms of NMS may include high fever, sweating (diaphoresis), severe muscle stiffness or rigidity, confusion, loss of consciousness, high blood pressure, rapid heartbeat, and changes in your breathing.
- Extrapyramidal side effects (EPS) include:
- Tardive dyskinesia (TD). TD usually occurs after long term use of antipsychotics and usually causes movement problems affecting the tongue, lips, jaw, face, and extremities.
- Metabolic changes including high blood sugar (hyperglycemia), diabetes mellitus, increase in blood cholesterol, and weight gain.
- High blood levels of prolactin. Prolactin is a hormone that allows the production of breast milk. High levels of prolactin may cause menstrual abnormalities, leakage of milk from the breast, development of breasts in (males gynecomastia), and erection problems in men (erectile dysfunction).
Quick GuideSchizophrenia: Symptoms, Types, Causes, Treatment
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