Is paliperidone palmitate safe to take if I'm pregnant or breastfeeding?

Fetuses exposed to antipsychotics during the third trimester of pregnancy are at risk for extrapyramidal and withdrawal symptoms after birth. Symptoms reported included agitation, hypertonia, hypotonia, tremor, somnolence, depressed breathing, and feeding disorder. Currently there is no data on the use of Invega trinza during pregnancy. Invega trinza should only be used during pregnancy if the potential benefit to the mother outweighs the potential for side effects in the fetus.

A pregnancy exposure registry has been established to monitor the use of atypical antipsychotics, including Invega trinza, during pregnancy. All pregnant women treated with atypical antipsychotics are advised to enroll in this pregnancy registry and report any side effects.

Invega trinza is known to enter human milk but its effects on the breastfeeding infant or milk production is not yet known.

What else should I know about paliperidone palmitate?

What preparations of paliperidone palmitate are available?

Extended-release injectable suspension: 273, 410, 546, or 819 mg

How should I keep paliperidone palmitate stored?

Invega trinza should be stored at room temperature between 15 C to 30 C (59 F and 86 F).

REFERENCE: FDA Prescribing Information.

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