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- What is paliperidone palmitate, and how does it work (mechanism of action)?
- What brand names are available for paliperidone palmitate?
- Is paliperidone palmitate available as a generic drug?
- Do I need a prescription for paliperidone palmitate?
- What are the side effects of paliperidone palmitate?
- What is the dosage for paliperidone palmitate?
- Which drugs or supplements interact with paliperidone palmitate?
- Is paliperidone palmitate safe to take if I'm pregnant or breastfeeding?
- What else should I know about paliperidone palmitate?
What is paliperidone palmitate, and how does it work (mechanism of action)?
Invega trinza (paliperidone palmitate) is an atypical antipsychotic used to treat schizophrenia. It is a longer acting form of Invega sustenna and Invega. Other atypical antipsychotic drugs include olanzapine (Zyprexa), quetiapine (Seroquel), ziprasidone (Geodon), asenapine (Saphris), iloperidone (Fanapt) and aripiprazole (Abilify).
Atypical antipsychotics differ from typical antipsychotics because they cause a lesser degree of movement (extrapyramidal) side effects and constipation.
The exact mechanism of action of paliperidone is not known, but, like other anti-psychotics, it is believed that paliperidone affects the way the brain works by interfering with communication among the brain's nerves. Nerves communicate with each other by making and releasing chemicals called neurotransmitters. The neurotransmitters travel to other nearby nerves where they attach to receptors on the nerves. The attachment of the neurotransmitters either stimulates or inhibits the function of the nearby nerves. Paliperidone blocks several of the receptors on nerves including dopamine type 2, serotonin type 2, and alpha 2 adrenergic receptors. It is believed that many psychotic illnesses are caused by abnormal communication among nerves in the brain and that by altering communication through neurotransmitters, paliperidone can alter the psychotic state. Invega trinza was approved by the FDA in May 2015.
What brand names are available for paliperidone palmitate?
Is paliperidone palmitate available as a generic drug?
GENERIC AVAILABLE: No
Do I need a prescription for paliperidone palmitate?
What are the side effects of paliperidone palmitate?
The most common side effects include
- injection site reaction,
- weight gain,
- upper respiratory tract infection,
- feeling restlessness or difficulty sitting still,
- stiffness and shuffling walk,
- tremors, and
- slow movements.
Less common but serious side effects are increased risk of stroke in elderly patients with dementia-related psychosis.
Neuroleptic malignant syndrome or NMS is a rare but serious side effect associated with the use of antipsychotics. Neuroleptic malignant syndrome may result in death and must be treated in the hospital. Signs and symptoms of heuroleptic malignant syndrome may include
- high fever,
- sweating (diaphoresis),
- severe muscle stiffness or rigidity,
- loss of consciousness,
- high blood pressure,
- rapid heartbeat, and
- changes in breathing breathing.
Extrapyramidal side effects include:
- Dystonia are painful spasms of the oral, throat, or neck muscles that may cause problems with speech, swallowing, and stiff neck.
- Akathisia are feelings of restlessness or difficulty sitting still.
- Pseudoparkinsonism is drug induced Parkinson's symptoms.
- Tardive dyskinesia usually occurs after long term use of antipsychotics and usually presents with movement problems affecting the tongue, lips, jaw, face, and extremities.
- Metabolic changes including high blood sugar (hyperglycemia), diabetes mellitus, increase in blood cholesterol, and weight gain.
- High blood levels of prolactin. Prolactin is a hormone that allows the production of breast milk. High levels of prolactin may cause menstrual abnormalities, leakage of milk from the breast, development of breasts in males (gynecomastia), and erection problems in men.
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