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The Cleveland Clinic

Pain Management: Musculoskeletal Pain

Musculoskeletal pain is pain that affects the muscles, ligaments and tendons, along with the bones.

What Causes Musculoskeletal Pain?

The causes of musculoskeletal pain are varied. Muscle tissue can be damaged with the wear and tear of daily activities. Trauma to an area (jerking movements, auto accidents, falls, fractures, sprains, dislocations, and direct blows to the muscle) also can cause musculoskeletal pain. Other causes of pain include postural strain, repetitive movements, overuse, and prolonged immobilization. Changes in posture or poor body mechanics may bring about spinal alignment problems and muscle shortening, therefore causing other muscles to be misused and become painful.

What Are the Symptoms of Musculoskeletal Pain?

People with musculoskeletal pain sometimes complain that their entire bodies ache. Their muscles may feel like they have been pulled or overworked. Sometimes the muscles twitch or burn. Symptoms vary from person to person, but the common symptoms are:

  • Pain
  • Fatigue
  • Sleep disturbances

How Is Musculoskeletal Pain Diagnosed?

Your doctor will conduct a thorough physical examination and medical history. In addition, your doctor may perform diagnostic studies to confirm the diagnosis.

How Is Musculoskeletal Pain Treated?

Different types of manual therapy, or mobilization, can be used to treat people with spinal alignment problems. For acute musculoskeletal pain, these techniques have been shown to speed recovery.

In patients with musculoskeletal disorders such as fibromyalgia, medications to increase the body's level of serotonin and norepinephrine (neurotransmitters that modulate sleep, pain, and immune system function) are prescribed in low doses. Some of the medicines used to aid sleep include Ambien, Klonopin, and Desyrel.

Other treatments may include:

  • Injections with anesthetic or anti-inflammatory medications in or around the painful sites
  • Exercise that includes muscle strengthening and stretching
  • Physical or occupational therapy
  • Acupuncture or acupressure
  • Relaxation/biofeedback techniques
  • Osteopathic manipulation (a whole system of evaluation and treatment designed to achieve and maintain health by restoring normal function to the body)
  • Chiropractic care
  • Therapeutic massage

Reviewed by the doctors at The Cleveland Clinic Neuroscience Center.
Edited by Charlotte E. Grayson, MD, June 2004.

Portions of this page © The Cleveland Clinic 2000-2003


Last Editorial Review: 2/4/2005 5:02:29 PM




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Polymyositis is a disease of muscle featuring inflammation of the muscle fibers. The cause of the disease is not known. It begins when white blood cells, the immune cells of inflammation, spontaneously invade muscles. The muscles affected are typically those closest to the trunk or torso. This results in weakness that can be severe. Polymyositis is a chronic illness with periods of increased symptoms, called flares or relapses, and minimal or no symptoms, known as remissions.

Polymyositis is slightly more common in females. It affects all age groups, although its onset is most common in middle childhood and in the 20s. Polymyositis occurs throughout the world. Polymyositis can be associated with skin rash and is then referred to as "dermatomyositis." It also can affect other areas of the body and is, therefore, referred to as a systemic illness. Occasionally, it is associated with cancer or with other diseases of connective tiss...

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