Dr. Shiel received a Bachelor of Science degree with honors from the University of Notre Dame. There he was involved in research in radiation biology and received the Huisking Scholarship. After graduating from St. Louis University School of Medicine, he completed his Internal Medicine residency and Rheumatology fellowship at the University of California, Irvine. He is board-certified in Internal Medicine and Rheumatology.
Melissa Conrad Stöppler, MD, is a U.S. board-certified Anatomic Pathologist with subspecialty training in the fields of Experimental and Molecular Pathology. Dr. Stöppler's educational background includes a BA with Highest Distinction from the University of Virginia and an MD from the University of North Carolina. She completed residency training in Anatomic Pathology at Georgetown University followed by subspecialty fellowship training in molecular diagnostics and experimental pathology.
Catherine Burt Driver, MD, is board certified in internal medicine and rheumatology by the American Board of Internal Medicine. Dr. Driver is a member of the American College of Rheumatology. She currently is in active practice in the field of rheumatology in Mission Viejo, Calif., where she is a partner in Mission Internal Medical Group.
Paget's disease is a chronic condition of bone characterized by disorder of the normal bone remodeling process. Normal bone has a balance of forces that act to lay down new bone and take up old bone. This relationship (referred to as "bone remodeling") is essential for maintaining the normal calcium levels in our blood. In bone affected by Paget's disease, the bone remodeling is disturbed and not synchronized. As a result, the bone that is formed is abnormal, enlarged, not as dense, brittle, and prone to breakage (fracture).
Paget's disease affects older skeletal bone of adults. It's estimated that 1% of adults in the U.S. have Paget's disease. There is also
an extremely rare form of Paget's
disease in children, referred to as juvenile Paget's disease. Paget's disease is
also known as osteitis deformans.
What causes Paget's disease?
It is not known what causes Paget's disease. Recently, certain genes have been associated with Paget's disease, including the Sequestrosome 1 gene on chromosome 5. Virus infection may be necessary to trigger Paget's disease in people who have inherited the genetic tendency to develop the condition by having these genes.
What are Paget's disease symptoms?
Paget's disease commonly causes no symptoms and is often incidentally noted when
X-ray tests are obtained for other reasons. However, Paget's disease can cause
bone pain, deformity, fracture, and arthritis. The bone pain of Paget's disease
is located in the affected bone. The most common bones affected by Paget's
disease include the spine, the thigh bone (femur), the pelvis, the skull, the
collarbone (clavicle), and the upper arm bone (humerus).
The symptoms of Paget's disease depend on the bones affected and the severity
of the disease. Enlarged bones can pinch adjacent nerves, causing tingling
and numbness. Bowing of the legs can occur. Hip or knee involvement can lead to
limping, as well as pain and stiffness of the hip or knee. Headache, loss of
vision, and hearing loss can occur when bones of the skull are affected. With
very widespread Paget's disease, it is possible to develop congestive heart
failure due to an increased workload on the heart.
Paget's Disease of Bone and Osteoarthritis: Different Yet Related
Paget's disease and osteoarthritisare completely different disorders that share some of
the same symptoms; namely, joint and bone pain. This fact sheet describes the
differences between Paget's disease of bone and osteoarthritis, the similarities
in their symptoms, how Paget's disease can cause osteoarthritis, and issues
related to diagnosis and treatment.
What is Paget's disease?
Paget's disease is a chronic disorder that can
result in enlarged and misshapen bones. The excessive breakdown and formation of
bone tissue causes affected bone to weaken, resulting in pain, misshapen bones,
fractures, and other bone and joint problems, including osteoarthritis. Paget's
disease typically is localized, affecting just one or a few bones, as opposed to
osteoporosis, for example, which affects all the bones in the body. Scientists
do not know for sure what causes Paget's disease.
What is osteoarthritis?
Osteoarthritis is a condition that causes changes in
cartilage, the elastic tissue that cushions the joints. Healthy cartilage allows
bones to glide over one another, while absorbing energy from the shock of
physical movement. In osteoarthritis, the surface layer of cartilage breaks down
and wears away. This allows bones under the cartilage to rub together, causing
pain, swelling, and loss of motion of the joint.