oxycodone and acetaminophen, Percocet, Roxicet, Tylox, Endocet (discontinued), Oxycet, (cont.)

Pharmacy Author:
Medical and Pharmacy Editor:

PRESCRIBED FOR: Oxycodone/acetaminophen is prescribed for the relief of moderate to moderately-severe pain.

SIDE EFFECTS: The most frequent adverse reactions of oxycodone/acetaminophen are:

Other important side effects include:

  • drowsiness,
  • constipation, and
  • spasm of the ureter, which can lead to difficulty in urinating.

Oxycodone can depress breathing and, therefore, is used with caution in elderly, debilitated patients and in patients with serious lung disease. Oxycodone can impair thinking and the physical abilities required for driving or operating machinery. Oxycodone can be habit-forming. Mental and physical dependence can occur but are unlikely when used for short-term pain relief.



PREPARATIONS: Tablets: 2.5/325, 5/325, 7.5/500, 10/650 mg (oxycodone/acetaminophen); Capsules: 5/500 mg; Solution: 5/325 mg per teaspoonful.

STORAGE: Oxycodone/acetaminophen should be stored at room temperature in a sealed, light-resistant container.

DOSING: The dose of oxycodone/acetaminophen is variable and depends on the needs of the patient and specific circumstances. The usual dose is one tablet every six hours as needed. The maximum oxycodone/acetaminophen dose is 60 mg/4 g per day.

DRUG INTERACTIONS: Oxycodone, like other narcotic pain-relievers, increases the effect of drugs that slow brain function, such as alcohol, barbiturates, skeletal muscle relaxants, for example, carisoprodol (Soma), cyclobenzaprine (Flexeril), and benzodiazepines such as diazepam (Valium) and lorazepam (Ativan). Combined use of muscle relaxants or benzodiazepines and oxycodone may lead to increased respiratory depression.

Medically Reviewed by a Doctor on 1/13/2015

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