Percocet (oxycodone and acetaminophen, Roxicet, Tylox, Oxycet)

  • Pharmacy Author:
    Omudhome Ogbru, PharmD

    Dr. Ogbru received his Doctorate in Pharmacy from the University of the Pacific School of Pharmacy in 1995. He completed a Pharmacy Practice Residency at the University of Arizona/University Medical Center in 1996. He was a Professor of Pharmacy Practice and a Regional Clerkship Coordinator for the University of the Pacific School of Pharmacy from 1996-99.

  • Medical and Pharmacy Editor: Jay W. Marks, MD
    Jay W. Marks, MD

    Jay W. Marks, MD

    Jay W. Marks, MD, is a board-certified internist and gastroenterologist. He graduated from Yale University School of Medicine and trained in internal medicine and gastroenterology at UCLA/Cedars-Sinai Medical Center in Los Angeles.

Do I need a prescription for Percocet?

  • Yes

Why is Percocet prescribed to patients?

  • Percocet (oxycodone/acetaminophen) is prescribed for the relief of moderate to moderately-severe pain.

What are the side effects of Percocet?

The most frequent adverse reactions of Percocet (oxycodone/acetaminophen) include:

Other important side effects include:

  • Drowsiness
  • Constipation
  • Spasm of the ureter, which can lead to difficulty in urinating

Possible serious side effects include:

  • Severe reduction in blood pressure (hypotension)
  • Shock
  • Seizures
  • Paralytic ileus
  • Serious allergic reactions
  • Severe skin reactions

Oxycodone can depress breathing and, therefore, is used with caution in elderly, debilitated patients and in patients with serious lung disease. Oxycodone can impair thinking and the physical abilities required for driving or operating machinery.

Is Percocet addicting?

  • Oxycodone can be habit-forming. Mental and physical dependence can occur, but are unlikely when used for short-term pain relief.

Quick GuideChronic Pain: Causes and Solutions

Chronic Pain: Causes and Solutions

What is the dosage for Percocet?

  • The dose of Percocet (oxycodone/acetaminophen) is variable and depends on the needs of the patient and specific circumstances.
  • The usual dose is one tablet every six hours as needed.
  • The maximum oxycodone/acetaminophen dose is 60 mg/4 g per day.

Which drugs or supplements interact with Percocet?

  • Oxycodone, like other narcotic pain-relievers, increases the effect of drugs that slow brain function, such as alcohol, barbiturates, skeletal muscle relaxants, for example, carisoprodol (Soma), cyclobenzaprine (Flexeril), and benzodiazepines such as diazepam (Valium) and lorazepam (Ativan). Combined use of muscle relaxants or benzodiazepines and oxycodone may lead to increased respiratory depression.
  • Since oxycodone causes constipation, the use of antidiarrheals, for example, diphenoxylate (Lomotil) and loperamide (Imodium), in persons taking oxycodone, can lead to severe constipation.
  • Drugs which stimulate and also block opioid receptors, for example, pentazocine, nalbuphine (Nubain), butorphanol (Stadol), and buprenorphine (Subutex) may reduce the effect of oxycodone and may precipitate withdrawal symptoms.
  • A fatty meal may increase the absorption of oxycodone by 27%.

Is Percocet safe to use during pregnancy or while breastfeeding?

  • Safety of oxycodone/acetaminophen during pregnancy has not been established. Newborns of mothers who were taking oxycodone for a prolonged period may exhibit respiratory depression or withdrawal symptoms.
  • Small amounts of oxycodone are secreted in breast milk and may cause side effects in the newborn.

What brand names are available for oxycodone and acetaminophen?

  • Brand names available in the US include: Percocet, Primlev, Roxicet, Endocet, Xartemis XR
  • Discontinued brand names include Xolox, Tylox, Oxycet, and Roxilox.

Quick GuideChronic Pain: Causes and Solutions

Chronic Pain: Causes and Solutions

What else should I know about Percocet?

What preparations of Percocet are available?
  • Tablets: 2.5/325, 5/300, 5/325, 7.5/300, 7.5/325, 10/300, 10/325 mg (oxycodone/acetaminophen)
  • Tablets (Extended Release): 4.8/325 mg.
  • Solution: 5/325 mg per teaspoonful
How should I keep Percocet stored?

Oxycodone/acetaminophen should be stored at room temperature in a sealed, light-resistant container.

How does Percocet stop pain?
  • The precise mechanism of action of oxycodone is not known but may involve stimulation of opioid (narcotic) receptors in the brain. Oxycodone does not eliminate the sensation of pain but decreases discomfort by increasing tolerance to pain. In addition to tolerance to pain, oxycodone also causes sedation and respiratory depression. Acetaminophen is a non-narcotic pain-reliever and antipyretic (fever reducer). Acetaminophen relieves pain by elevating the threshold to sensing pain. It reduces fever through its action on the heat-regulating center of the brain. The combination of oxycodone and acetaminophen achieves greater pain relief than either taken separately.
  • The FDA approved oxycodone/acetaminophen combinations in February 1980.

Reference: FDA Prescribing Information

Last Editorial Review: 7/28/2016

FDA Logo

Report Problems to the Food and Drug Administration

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.

Reviewed on 7/28/2016
References
Reference: FDA Prescribing Information

Health Solutions From Our Sponsors