oxycodone and acetaminophen, Percocet, Roxicet, Tylox, Endocet (discontinued), Oxycet,

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Medical and Pharmacy Editor:

GENERIC NAME: oxycodone and acetaminophen

BRAND NAMES: Percocet, Roxicet, Tylox, Endocet (discontinued), Oxycet, Roxilox

DRUG CLASS AND MECHANISM: Oxycodone is a strong narcotic pain-reliever and cough suppressant similar to morphine, codeine, and hydrocodone. The precise mechanism of action is not known but may involve stimulation of opioid (narcotic) receptors in the brain. Oxycodone does not eliminate the sensation of pain but decreases discomfort by increasing tolerance to pain. In addition to tolerance to pain, oxycodone also causes sedation and respiratory depression. Acetaminophen is a non-narcotic pain-reliever and antipyretic (fever reducer). Acetaminophen relieves pain by elevating the threshold to sensing pain. It reduces fever through its action on the heat-regulating center of the brain. The combination of oxycodone and acetaminophen achieves greater pain relief than either taken separately. The FDA approved oxycodone/acetaminophen combinations in February 1980.

PRESCRIPTION: Yes

GENERIC AVAILABLE: Yes

PREPARATIONS: Tablets: 2.5/325, 5/325, 7.5/500, 10/650 mg (oxycodone/acetaminophen); Capsules: 5/500 mg; Solution: 5/325 mg per teaspoonful.




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