oxycodone, OxyContin, Roxicodone, Oxecta (cont.)

Pharmacy Author:
Medical and Pharmacy Editor:

Oxycodone can depress breathing and is used with caution in elderly, debilitated patients and in patients with serious lung disease.

Oxycodone can impair thinking and the physical abilities required for driving or operating machinery. Oxycodone is habit forming. Mental and physical dependence can occur but are unlikely when used for short-term pain relief. If oxycodone is suddenly withdrawn after prolonged use, symptoms of withdrawal may develop. The dose of oxycodone should be gradually reduced in order to avoid withdrawal symptoms.

GENERIC AVAILABLE: Yes

PRESCRIPTION: Yes

PREPARATIONS:

  • Tablets (Immediate Release): 5, 7.5, 10, 15, 20, and 30 mg.
  • Capsules (Immediate Release): 5 mg.
  • Tablets (Extended Release): 10, 15, 20, 30, 40, 60, and 80.
  • Oral Concentrate: 20 mg/ml.
  • Oral Solution: 5 mg/5 ml

STORAGE: Oxycodone should be stored between 15 C and 30 C (59 F and 86 F). Open bottles of oral solution should be destroyed after 90 days.

DOSING:

  • The usual starting dose using immediate release oxycodone tablets is 5 to 30 mg every 4 to 6 hours. Patients who have never received opioids should start with 5-15 mg every 4 to 6 hours. Some patients may require 30 mg or more every 4 hours.
  • The usual starting dose using extended release tablets is 10 mg every 12 hours. Extended release tablets are used when around the clock treatment is required for an extended period of time. Extended release tablets should not be broken, crushed or chewed but should be swallowed whole. Braking, crushing or chewing extended release tablets may lead to rapid absorption of the drug and dangerous levels of oxycodone.
  • The 60 and 80 tablets or single doses greater than 40 mg should only be used by patients who have been using opioids and have become tolerant to opioid therapy. Administration of large doses to opioid-naïve patients may lead to profound depression of breathing.
  • The usual adult dose of the oral concentrate (20 mg/ml) is 5 mg every 6 hours.
  • The usual adult dose for the oral solution (5 mg/5 ml) is 10-30 mg every 4 hours.

DRUG INTERACTIONS: Oxycodone, like other narcotic pain-relievers, increases the effects of drugs that slow brain function, such as:

Medically Reviewed by a Doctor on 2/25/2015


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