oxycodone, OxyContin, Roxicodone, Oxecta

  • Pharmacy Author:
    Omudhome Ogbru, PharmD

    Dr. Ogbru received his Doctorate in Pharmacy from the University of the Pacific School of Pharmacy in 1995. He completed a Pharmacy Practice Residency at the University of Arizona/University Medical Center in 1996. He was a Professor of Pharmacy Practice and a Regional Clerkship Coordinator for the University of the Pacific School of Pharmacy from 1996-99.

  • Medical and Pharmacy Editor: Jay W. Marks, MD
    Jay W. Marks, MD

    Jay W. Marks, MD

    Jay W. Marks, MD, is a board-certified internist and gastroenterologist. He graduated from Yale University School of Medicine and trained in internal medicine and gastroenterology at UCLA/Cedars-Sinai Medical Center in Los Angeles.

Surprising Reasons You're in Pain Slideshow

PREPARATIONS:

  • Tablets (Immediate Release): 5, 7.5, 10, 15, 20, and 30 mg.
  • Capsules (Immediate Release): 5 mg.
  • Tablets (Extended Release): 10, 15, 20, 30, 40, 60, and 80.
  • Oral Concentrate: 20 mg/ml.
  • Oral Solution: 5 mg/5 ml

DRUG INTERACTIONS:

  • Oxycodone, like other narcotic pain-relievers, increases the effects of drugs that slow brain function, such as:
  • Combined use of the above drugs and oxycodone may lead to increased respiratory depression.
  • Oxycodone should not be taken with any of the monoamine oxidase inhibitor (MAOI) class of antidepressants, for example, isocarboxazid (Marplan), phenelzine (Nardil), tranylcypromine (Parnate), selegiline (Eldepryl), and procarbazine (Matulane) or other drugs that inhibit monoamine oxidase, for example, linezolid (Zyvox). Such combinations may lead to confusion, high blood pressure, tremor, hyperactivity, coma, and death. Oxycodone should not be administered within 14 days of stopping an MAOI.
  • Since oxycodone causes constipation, the use of antidiarrheals, for example, diphenoxylate and atropine (Lomotil) and loperamide (Imodium), in persons taking oxycodone, can lead to severe constipation.
  • Drugs which stimulate and also block opioid receptors for example, pentazocine, nalbuphine (Nubain), butorphanol (Stadol), and buprenorphine (Subutex) may reduce the effect of oxycodone and may precipitate withdrawal symptoms.
  • Combining oxycodone with drugs that affect activity of certain liver enzymes or discontinuing such drugs may result in fatal oxycodone overdose.
  • A fatty meal may increase the absorption of oxycodone by 27%.
Medically Reviewed by a Doctor on 7/7/2016

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