oxaprozin, Daypro (cont.)
Omudhome Ogbru, PharmD
Omudhome Ogbru, PharmD
Dr. Ogbru received his Doctorate in Pharmacy from the University of the Pacific School of Pharmacy in 1995. He completed a Pharmacy Practice Residency at the University of Arizona/University Medical Center in 1996. He was a Professor of Pharmacy Practice and a Regional Clerkship Coordinator for the University of the Pacific School of Pharmacy from 1996-99.
Medical and Pharmacy Editor:
DOSING: The usual dose of oxaprozin is 600 or 1200 mg once daily taken with food. The maximum dose is 1800 mg daily. The total daily dose may be divided into multiple doses if single daily doses are not tolerated.
DRUG INTERACTIONS: Oxaprozin may increase the blood levels of lithium (Eskalith) by reducing the excretion of lithium by the kidneys. Increased levels of lithium may lead to lithium toxicity.
Oxaprozin may reduce the blood pressure lowering effects of blood pressure medications. This may occur because prostaglandins play a role in the regulation (reduction) of blood pressure.
When oxaprozin is used in combination with methotrexate (Rheumatrex, Trexall) or aminoglycoside antibiotics (for example, gentamicin) the blood levels of methotrexate or aminoglycoside may increase, presumably because the elimination of methotrexate or aminoglycoside is reduced. This may lead to more side effects from methotrexate or aminoglycoside.
Individuals taking oral blood thinners or anticoagulants, for example, warfarin, (Coumadin), should avoid oxaprozin because oxaprozin also thins the blood, and excessive blood thinning may lead to bleeding.
PREGNANCY: There are no adequate studies of oxaprozin in pregnant women. Therefore, oxaprozin is not recommended during pregnancy.
NURSING MOTHERS: It is not known whether oxaprozin is excreted in breast milk.
SIDE EFFECTS: The most common side effects from oxaprozin are rash, ringing in the ears, headaches, dizziness, drowsiness, abdominal pain, nausea, diarrhea, constipation, heartburn, fluid retention and shortness of breath.
Report Problems to the Food and Drug Administration
You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.
Need help identifying pills and medications?
Back to Medications Index