DRUG INTERACTIONS: Oxaprozin may increase the blood levels of lithium (Eskalith, Lithobid) by reducing the excretion of lithium by the kidneys. Increased levels of lithium may lead to lithium toxicity.
Oxaprozin may reduce the blood pressure lowering effects of blood pressure medications. This may occur because prostaglandins play a role in the regulation (reduction) of blood pressure.
When oxaprozin is used in combination with methotrexate (Rheumatrex, Trexall) or aminoglycoside antibiotics (for example, gentamicin) the blood levels of methotrexate or aminoglycoside may increase, presumably because the elimination of methotrexate or aminoglycoside is reduced. This may lead to more side effects from methotrexate or aminoglycoside.
Individuals taking oral blood thinners or anticoagulants, for example, warfarin, (Coumadin), should avoid oxaprozin because oxaprozin also thins the blood, and excessive blood thinning may lead to bleeding.
Oxaprozin increases the negative effect of cyclosporine on kidney function.
If aspirin is taken with oxaprozin there may be an increased risk for developing an ulcer.
Persons who have more than 3 alcoholic beverages per day may be at increased risk of developing stomach ulcers when taking oxaprozin or other NSAIDs.
PREGNANCY: There are no adequate studies of oxaprozin in pregnant women. Therefore, oxaprozin is not recommended during pregnancy.
NURSING MOTHERS: It is not known whether oxaprozin is excreted in breast milk.
SIDE EFFECTS: The most common side effects from oxaprozin are rash, ringing in the ears, headaches, dizziness, drowsiness, abdominal pain, nausea, diarrhea, constipation, heartburn, fluid retention, and shortness of breath.
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