oxaprozin, Daypro (cont.)

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PREPARATIONS: Tablets: 600 mg

STORAGE: Oxaprozin should be stored at room temperature below 25 C (77 F) protected from moisture in a sealed container.

PRESCRIBED FOR: Oxaprozin is used for the treatment of inflammation and the pain, fever, swelling and tenderness of joints caused by rheumatoid arthritis or osteoarthritis.

DOSING: The usual dose of oxaprozin is 600 or 1200 mg once daily taken with food. The maximum dose is 1800 mg daily. The total daily dose may be divided into multiple doses if single daily doses are not tolerated.

DRUG INTERACTIONS: Oxaprozin may increase the blood levels of lithium (Eskalith, Lithobid) by reducing the excretion of lithium by the kidneys. Increased levels of lithium may lead to lithium toxicity.

Oxaprozin may reduce the blood pressure lowering effects of blood pressure medications. This may occur because prostaglandins play a role in the regulation (reduction) of blood pressure.

When oxaprozin is used in combination with methotrexate (Rheumatrex, Trexall) or aminoglycoside antibiotics (for example, gentamicin) the blood levels of methotrexate or aminoglycoside may increase, presumably because the elimination of methotrexate or aminoglycoside is reduced. This may lead to more side effects from methotrexate or aminoglycoside.

Individuals taking oral blood thinners or anticoagulants, for example, warfarin, (Coumadin), should avoid oxaprozin because oxaprozin also thins the blood, and excessive blood thinning may lead to bleeding.

Oxaprozin increases the negative effect of cyclosporine on kidney function.

Medically Reviewed by a Doctor on 11/6/2014

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